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Ephrin Type A Receptor 2 (EPHA2)

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ECK; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK

Ephrin Type A Receptor 2 (EPHA2)
CCC E115
HGNC 3386
MGI 95278
PubMed 23629968
RGD 1307204
UniProt P29317
Wiki EPHA2
ephrin type-A receptor 2) is a protein belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands.Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g., skin, intestine, lung, and ovary.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type A Receptor 2 (EPHA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type A Receptor 2 (EPHA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type A Receptor 2 (EPHA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type A Receptor 2 (EPHA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type A Receptor 2 (EPHA2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type A Receptor 2 (EPHA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type A Receptor 2 (EPHA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type A Receptor 2 (EPHA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type A Receptor 2 (EPHA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type A Receptor 2 (EPHA2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type A Receptor 2 (EPHA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type A Receptor 2 (EPHA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type A Receptor 2 (EPHA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type A Receptor 2 (EPHA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type A Receptor 2 (EPHA2) ELISA Kit Customized Service Offer
  1. "cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases."Mol. Cell. Biol. 10:6316-6324(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."Arthritis Res. Ther. 10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Unified nomenclature for Eph family receptors and their ligands, the ephrins."Cell 90:403-404(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation."Nat. Cell Biol. 2:62-69(2000) [PubMed] [Europe PMC] [Abstract]
  7. "EphA2 overexpression causes tumorigenesis of mammary epithelial cells."Cancer Res. 61:2301-2306(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation."J. Biol. Chem. 277:39274-39279(2002) [PubMed] [Europe PMC] [Abstract]
  9. "EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability."J. Biol. Chem. 280:42375-42382(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK."Int. J. Oncol. 30:865-871(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation."J. Biol. Chem. 282:2683-2694(2007) [PubMed] [Europe PMC] [Abstract]
  12. "EphA2 is an essential mediator of UV radiation-induced apoptosis."Cancer Res. 68:1691-1696(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor."Oncogene 27:7260-7273(2008) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt."Cancer Cell 16:9-20(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis."Mol. Cancer Res. 7:1021-1032(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism."J. Cell Biol. 190:461-477(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1."Mol. Biol. Cell 21:3902-3914(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Solution structure of the first Sam domain of Odin and binding studies with the EphA2 receptor."Biochemistry 51:2136-2145(2012) [PubMed] [Europe PMC] [Abstract]
  25. "The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma-associated herpesvirus."Nat. Med. 18:961-966(2012) [PubMed] [Europe PMC] [Abstract]
  26. "Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration."Mol. Cell. Biol. 33:1430-1441(2013) [PubMed] [Europe PMC] [Abstract]
  27. "Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors."PLoS ONE 8:E69473-E69473(2013) [PubMed] [Europe PMC] [Abstract]
  28. "Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography."Structure 10:1659-1667(2002) [PubMed] [Europe PMC] [Abstract]
  29. "Solution structure of the C-terminal SAM-domain of EPHAA2: ephrin type-A receptor 2 precursor (EC 2.7.10.1)."Submitted (JAN-2008) to the PDB data bank
  30. "Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex."EMBO Rep. 10:722-728(2009) [PubMed] [Europe PMC] [Abstract]
  31. "Ephrin A1 bound to the ligand binding domain of the human ephrin A2 (EPHA2) receptor protein kinase."Submitted (FEB-2009) to the PDB data bank
  32. "Left-handed dimer of EPHA2 transmembrane domain helix packing diversity among receptor tyrosine kinases."Submitted (AUG-2009) to the PDB data bank
  33. "Architecture of Eph receptor clusters."Proc. Natl. Acad. Sci. U.S.A. 107:10860-10865(2010) [PubMed] [Europe PMC] [Abstract]
  34. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  35. "The EPHA2 gene is associated with cataracts linked to chromosome 1p."Mol. Vis. 14:2042-2055(2008) [PubMed] [Europe PMC] [Abstract]
  36. "Mutations of the EPHA2 receptor tyrosine kinase gene cause autosomal dominant congenital cataract."Hum. Mutat. 30:E603-E611(2009) [PubMed] [Europe PMC] [Abstract]
  37. "EPHA2 is associated with age-related cortical cataract in mice and humans." PLoS Genet. 5:E1000584-E1000584(2009) [PubMed] [Europe PMC] [Abstract]
  38. "Human cataract mutations in EPHA2 SAM domain alter receptor stability and function."PLoS ONE 7:E36564-E36564(2012) [PubMed] [Europe PMC] [Abstract]