≡

Ephrin A1 (EFNA1)

[Edit]

B61; ECKLG; EFL1; EPLG1; LERK1; TNFAIP4; EPH-related receptor tyrosine kinase ligand 1; Tumor necrosis factor alpha-induced protein 4; Immediate early response protein B61

Ephrin A1 (EFNA1)
CCC E107
HGNC 3221
MGI 103236
PubMed 15649254
RGD 620388
UniProt P20827
Wiki EFNA1
Ephrin-A1 is a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE107Hu01 Recombinant Ephrin A1 (EFNA1) Positive Control; Immunogen; SDS-PAGE; WB.
APE107Hu01 Active Ephrin A1 (EFNA1) Cell culture; Activity Assays.
Antibodies PAE107Hu01 Polyclonal Antibody to Ephrin A1 (EFNA1) WB; IHC; ICC; IP.
MAE107Hu21 Monoclonal Antibody to Ephrin A1 (EFNA1) WB; IHC; ICC; IP.
Assay Kits SEE107Hu ELISA Kit for Ephrin A1 (EFNA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin A1 (EFNA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin A1 (EFNA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin A1 (EFNA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin A1 (EFNA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin A1 (EFNA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin A1 (EFNA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin A1 (EFNA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin A1 (EFNA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin A1 (EFNA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin A1 (EFNA1) ELISA Kit Customized Service Offer
  1. "A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein."Mol. Cell. Biol. 10:5830-5838(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins."Oncogene 10:299-306(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK."Int. J. Oncol. 30:865-871(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor."Oncogene 27:7260-7273(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase."J. Biol. Chem. 288:18448-18457(2013) [PubMed] [Europe PMC] [Abstract]
  9. "Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex."EMBO Rep. 10:722-728(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Architecture of Eph receptor clusters."Proc. Natl. Acad. Sci. U.S.A. 107:10860-10865(2010) [PubMed] [Europe PMC] [Abstract]