Protocadherin 21 (PCDH21)

[Edit]

CDHR1; PRCAD; Cadherin-Related Family Member 1; Photoreceptor cadherin

Protocadherin 21 (PCDH21)
PCDH21 is a member of the cadherin superfamily of calcium-dependent cell-cell adhesion molecules. This non-classical cadherin appears to be exclusively expressed in the mitral and tufted cells in the main and accessory olfactory bulbs of the brain, suggesting a possible role in the formation and maintenance of neuronal networks. Alternatively spliced transcript variants encoding different isoform have been identified.
Protocadherins were discovered by Shintaro Suzuki's group, when they used PCR to find new members of the cadherin family. This prevalence in a wide range of species suggested that the fragments were part of an ancient cadherin and were thus termed "Protocadherins" as the "first cadherins".

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protocadherin 21 (PCDH21) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protocadherin 21 (PCDH21) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protocadherin 21 (PCDH21) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protocadherin 21 (PCDH21) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protocadherin 21 (PCDH21) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protocadherin 21 (PCDH21) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protocadherin 21 (PCDH21) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protocadherin 21 (PCDH21) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protocadherin 21 (PCDH21) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protocadherin 21 (PCDH21) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protocadherin 21 (PCDH21) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protocadherin 21 (PCDH21) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protocadherin 21 (PCDH21) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protocadherin 21 (PCDH21) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protocadherin 21 (PCDH21) ELISA Kit Customized Service Offer
  1. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs."Brain Res. Mol. Brain Res. 94:85-95(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice." J. Clin. Invest. 118:2908-2916(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in PCDH21 cause autosomal recessive cone-rod dystrophy."J. Med. Genet. 47:665-669(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Protocadherin-21 (PCDH21), a candidate gene for human retinal dystrophies."Mol. Vis. 11:929-933(2005) [PubMed] [Europe PMC] [Abstract]