Protocadherin Gamma B4 (PCDHgB4)
[Edit]CDH20; FIB2; Fibroblast cadherin-2; Fibroblast Cadherin FIB2; Cadherin 20
![Protocadherin Gamma B4 (PCDHgB4)](/upload/item/img/Protocadherin-Gamma-B4-(PCDHgB4)-94054.jpg)
PCDHGB4 is 1 of 22 tandemly arranged genes within the PCDHG gene cluster on chromosome 5q31. The 22 PCDHG genes function as 'variable' exons that are individually spliced to a downstream constant region to form distinct PCDHG transcripts. The variable PCDHG exons encode the extracellular and transmembrane domains of the protocadherin protein, and the common region encodes the intracellular domain. To elucidate the molecular basis of fibroblast cell-cell adhesion, Matsuyoshi and Imamura (1997) investigated cadherin expression in human fibroblasts by RT-PCR using degenerate primers based on well-conserved amino acid sequences of cadherins. They isolated a partial cDNA encoding PCDHGB4, which they called FIB2. RT-PCR analysis revealed that FIB2 is expressed in fibroblasts but not in melanocytes or keratinocytes.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Protocadherin Gamma B4 (PCDHgB4) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Protocadherin Gamma B4 (PCDHgB4) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Protocadherin Gamma B4 (PCDHgB4) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Protocadherin Gamma B4 (PCDHgB4) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Protocadherin Gamma B4 (PCDHgB4) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Protocadherin Gamma B4 (PCDHgB4) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Protocadherin Gamma B4 (PCDHgB4) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Protocadherin Gamma B4 (PCDHgB4) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Protocadherin Gamma B4 (PCDHgB4) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Protocadherin Gamma B4 (PCDHgB4) | ELISA Kit Customized Service Offer |
- "A striking organization of a large family of human neural cadherin-like cell adhesion genes."Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Multiple cadherins are expressed in human fibroblasts."Biochem. Biophys. Res. Commun. 235:355-358(1997) [PubMed] [Europe PMC] [Abstract]