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Cannabinoid Receptor 2, Macrophage (CNR2)

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CB2; CX5

Cannabinoid Receptor 2, Macrophage (CNR2)
CCC E045
HGNC 2160
MGI 104650
PubMed 11479216
RGD 619713
UniProt P34972
Wiki CNR2
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Cannabinoid receptor 2 is a G protein-coupled receptor from the cannabinoid receptor family. It is closely related to the cannabinoid receptor 1 which is responsible for the psychoactive properties of tetrahydrocannabinol, the active principle of marijuana.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cannabinoid Receptor 2, Macrophage (CNR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cannabinoid Receptor 2, Macrophage (CNR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cannabinoid Receptor 2, Macrophage (CNR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cannabinoid Receptor 2, Macrophage (CNR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cannabinoid Receptor 2, Macrophage (CNR2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cannabinoid Receptor 2, Macrophage (CNR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cannabinoid Receptor 2, Macrophage (CNR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cannabinoid Receptor 2, Macrophage (CNR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cannabinoid Receptor 2, Macrophage (CNR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cannabinoid Receptor 2, Macrophage (CNR2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE045Ra01 Recombinant Cannabinoid Receptor 2, Macrophage (CNR2) Positive Control; Immunogen; SDS-PAGE; WB.
RPE045Ra02 Recombinant Cannabinoid Receptor 2, Macrophage (CNR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE045Ra01 Polyclonal Antibody to Cannabinoid Receptor 2, Macrophage (CNR2) WB; IHC; ICC; IP.
MAE045Ra21 Monoclonal Antibody to Cannabinoid Receptor 2, Macrophage (CNR2) WB; IHC; ICC; IP.
Assay Kits SEE045Ra ELISA Kit for Cannabinoid Receptor 2, Macrophage (CNR2) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands."Genes Brain Behav. 8:519-530(2009) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations."Eur. J. Biochem. 232:54-61(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses."J. Biol. Chem. 274:20397-20405(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity."Mol. Pharmacol. 55:605-613(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells."J. Biol. Chem. 275:605-612(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Presence and regulation of the endocannabinoid system in human dendritic cells."Eur. J. Biochem. 269:3771-3778(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function."FEBS Lett. 531:290-294(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor."Biochem. Pharmacol. 65:1077-1085(2003) [PubMed] [Europe PMC] [Abstract]
  12. "2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism."J. Biol. Chem. 278:24469-24475(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors."J. Clin. Invest. 111:43-50(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains."J. Neurosci. 23:11136-11141(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study."Synapse 53:208-213(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons."Pain 138:667-680(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments."Biochem. Biophys. Res. Commun. 384:243-248(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects."PLoS ONE 3:E1640-E1640(2008) [PubMed] [Europe PMC] [Abstract]