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Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B)

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PPP1R4; PTG; Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL; Protein phosphatase 1 regulatory subunit 4; Protein phosphatase 1 subunit GL

Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B)
CCC E012
HGNC 14942
MGI 2177268
PubMed 23690473
RGD 621600
UniProt Q86XI6
The protein phosphatase-1 (PP1) catalytic subunit (PPP1CA) is regulated by targeting subunits, such as PP1R3B. PP1R3B suppresses the rate at which PP1 dephosphorylates (i.e., inactivates) glycogen phosphorylase (PYGL and enhances the rate at which it activates glycogen synthase (GYS2).
Northern blot analysis detected a 6.7-kb GL transcript that was highly expressed in skeletal muscle and heart, followed by liver. Low levels of GL were detected in placenta, lung, and kidney. In mouse and rat, Gl predominated in liver, but only low levels of Gl were detected in skeletal muscle and other tissues. Western blot analysis revealed a 33-kD GL protein that was expressed at similar levels in human liver and skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE012Hu01 Recombinant Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human skeletal muscle expresses a glycogen-targeting subunit of PP1 that is identical to the insulin-sensitive glycogen-targeting subunit G(L) of liver."Diabetes 51:591-598(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Expression and glycogenic effect of glycogen-targeting protein phosphatase 1 regulatory subunit GL in cultured human muscle."Biochem. J. 405:107-113(2007) [PubMed] [Europe PMC] [Abstract]
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  6. "Solution structure of the CBM21 domain from human protein phosphatase 1, regulatory (inhibitor) subunit 3B."Submitted (AUG-2007) to the PDB data bank