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Elongin C (ELOC)

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TCEB1; SI; Elo-C; Transcription Elongation Factor B(SIII)Polypeptide 1; Elongin 15 kDa subunit; RNA polymerase II transcription factor SIII subunit C

Elongin C (ELOC)
CCC D969
HGNC 11617
MGI 1915173
PubMed 12004003
RGD 620658
UniProt Q15369
Wiki TCEB1
Transcription elongation factor B polypeptide 1 is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C.
It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.Overexpressed in prostate cancer cell line PC- 3 and breast cancer cell line SK-BR-3.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD969Hu01 Recombinant Elongin C (ELOC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD969Hu01 Polyclonal Antibody to Elongin C (ELOC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Elongin C (ELOC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Elongin C (ELOC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Elongin C (ELOC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Elongin C (ELOC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Elongin C (ELOC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Elongin C (ELOC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Elongin C (ELOC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Elongin C (ELOC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Elongin C (ELOC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Elongin C (ELOC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Elongin C (ELOC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Elongin C (ELOC) ELISA Kit Customized Service Offer
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  9. "Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling."J. Biol. Chem. 280:7038-7048(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Structural basis for protein recognition by B30.2/SPRY domains."Mol. Cell 24:967-976(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase."J. Virol. 81:3428-3436(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5."Mol. Cell 48:692-704(2012) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function."Science 284:455-461(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL."Nature 417:975-978(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling."Science 296:1886-1889(2002) [PubMed] [Europe PMC] [Abstract]
  18. "Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation."Structure 15:1493-1504(2007) [PubMed] [Europe PMC] [Abstract]