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Estrogen Related Receptor Gamma (ERRg)

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ERR3; NR3B3; ERRG2; Estrogen receptor-related protein 3; Nuclear receptor subfamily 3 group B member 3

Estrogen Related Receptor Gamma (ERRg)
CCC D962
HGNC 3474
MGI 1347056
RGD 1303236
UniProt P62508
ERRg is a member of nuclear hormone receptor family of steroid hormone receptors. No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG. It also seems to be the target of bisphenol A.
There is evidence that bisphenol A functions as an endocrine disruptor by binding strongly to ERR-γ. BPA seems to binds strongly to ERR-γ (dissociation constant = 5.5 nM), but not to the estrogen receptor (ER). BPA binding to ERR-γ preserves its basal constitutive activity. It can also protect it from deactivation from the selective estrogen receptor modulator 4-hydroxytamoxifen.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Estrogen Related Receptor Gamma (ERRg) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Estrogen Related Receptor Gamma (ERRg) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Estrogen Related Receptor Gamma (ERRg) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Estrogen Related Receptor Gamma (ERRg) CLIA Kit Customized Service Offer
n/a ELISA Kit for Estrogen Related Receptor Gamma (ERRg) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Estrogen Related Receptor Gamma (ERRg) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Estrogen Related Receptor Gamma (ERRg) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Estrogen Related Receptor Gamma (ERRg) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Estrogen Related Receptor Gamma (ERRg) CLIA Kit Customized Service Offer
n/a ELISA Kit for Estrogen Related Receptor Gamma (ERRg) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Estrogen Related Receptor Gamma (ERRg) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Estrogen Related Receptor Gamma (ERRg) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Estrogen Related Receptor Gamma (ERRg) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Estrogen Related Receptor Gamma (ERRg) CLIA Kit Customized Service Offer
n/a ELISA Kit for Estrogen Related Receptor Gamma (ERRg) ELISA Kit Customized Service Offer
  1. "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR."Gene 228:101-109(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation of a gene encoding a novel member of the nuclear receptor superfamily from the critical region of Usher syndrome type IIa at 1q41."Genomics 50:382-384(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult."Mol. Endocrinol. 14:382-392(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3."J. Biol. Chem. 274:22618-22626(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma."Biochem. Biophys. Res. Commun. 312:975-982(2003) [PubMed] [Europe PMC] [Abstract]
  11. "PDSM, a motif for phosphorylation-dependent SUMO modification."Proc. Natl. Acad. Sci. U.S.A. 103:45-50(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Transcriptional ERRgamma2-mediated activation is regulated by sentrin-specific proteases."Biochem. J. 419:167-176(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif."Mol. Endocrinol. 22:570-584(2008) [PubMed] [Europe PMC] [Abstract]
  14. "An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha."Mol. Endocrinol. 24:1349-1358(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells."J. Biol. Chem. 288:25207-25218(2013) [PubMed] [Europe PMC] [Abstract]
  16. "Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3."Mol. Cell 9:303-313(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma."Bioorg. Med. Chem. Lett. 16:821-824(2006) [PubMed] [Europe PMC] [Abstract]
  18. "X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation."J. Biol. Chem. 281:37773-37781(2006) [PubMed] [Europe PMC] [Abstract]