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Estrogen Related Receptor Alpha (ERRa)

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ERR1; ERRa; ERRalpha; ESRL1; NR3B1; Estrogen receptor-like 1; Nuclear receptor subfamily 3 group B member 1

Estrogen Related Receptor Alpha (ERRa)
CCC D960
HGNC 3471
MGI 1346831
RGD 1583866
UniProt P11474
ERRα has wide tissue distribution but it is most highly expressed in tissue that preferentially use fatty acids as energy sources such as kidney, heart, cerebellum, intestine, and skeletal muscle. The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcription factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD960Hu01 Recombinant Estrogen Related Receptor Alpha (ERRa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD960Hu01 Polyclonal Antibody to Estrogen Related Receptor Alpha (ERRa) WB; IHC; ICC; IP.
MAD960Hu21 Monoclonal Antibody to Estrogen Related Receptor Alpha (ERRa) WB; IHC; ICC; IP.
Assay Kits SED960Hu ELISA Kit for Estrogen Related Receptor Alpha (ERRa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Estrogen Related Receptor Alpha (ERRa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Estrogen Related Receptor Alpha (ERRa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Estrogen Related Receptor Alpha (ERRa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Estrogen Related Receptor Alpha (ERRa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Estrogen Related Receptor Alpha (ERRa) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD960Ra01 Recombinant Estrogen Related Receptor Alpha (ERRa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD960Ra01 Polyclonal Antibody to Estrogen Related Receptor Alpha (ERRa) WB; IHC; ICC; IP.
MAD960Ra21 Monoclonal Antibody to Estrogen Related Receptor Alpha (ERRa) WB; IHC; ICC; IP.
Assay Kits SED960Ra ELISA Kit for Estrogen Related Receptor Alpha (ERRa) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Identification of a new class of steroid hormone receptors."Nature 331:91-94(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter."J. Biol. Chem. 271:5795-5804(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "SV40 early-to-late switch involves titration of cellular transcriptional repressors."Genes Dev. 7:2206-2219(1993) [PubMed] [Europe PMC] [Abstract]
  5. "The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene."Mol. Cell. Biol. 17:5400-5409(1997) [PubMed] [Europe PMC] [Abstract]
  6. "The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha)."J. Biol. Chem. 278:9013-9018(2003) [PubMed] [Europe PMC] [Abstract]
  7. "A single nucleotide in an estrogen-related receptor alpha site can dictate mode of binding and peroxisome proliferator-activated receptor gamma coactivator 1alpha activation of target promoters."Mol. Endocrinol. 20:302-310(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphorylation-dependent sumoylation of estrogen-related receptor alpha1."Biochemistry 46:9795-9804(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif."Mol. Endocrinol. 22:570-584(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha."Mol. Endocrinol. 24:1349-1358(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells."J. Biol. Chem. 288:25207-25218(2013) [PubMed] [Europe PMC] [Abstract]
  13. "Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha."J. Biol. Chem. 279:49330-49337(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop."J. Biol. Chem. 283:20220-20230(2008) [PubMed] [Europe PMC] [Abstract]