≡

Testicular Receptor 4 (TR4)

[Edit]

NR2C2; TAK1; TR2R1; hTAK1; Nuclear Receptor Subfamily 2,Group C,Member 2; Orphan nuclear receptor TAK1

Testicular Receptor 4 (TR4)
CCC D954
HGNC 7972
MGI 1352466
PubMed 21918225
RGD 3201
UniProt P49116
Wiki NR2C2
NR2C2, act as ligand-activated transcription factors. The proteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and a ligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes.
The cDNAs encode a predicted 615-amino acid human protein and a 596-amino acid rat protein that are 98% identical. The TR4 sequence is similar to that of the TR2 orphan . Together they appear to form a distinct subfamily. The 2 transcripts appeared to differ in the length of the 3-prime untranslated region. In mouse and rat testis, TR4 was expressed most abundantly in spermatocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD954Hu01 Recombinant Testicular Receptor 4 (TR4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD954Hu01 Polyclonal Antibody to Testicular Receptor 4 (TR4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Testicular Receptor 4 (TR4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testicular Receptor 4 (TR4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testicular Receptor 4 (TR4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testicular Receptor 4 (TR4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testicular Receptor 4 (TR4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testicular Receptor 4 (TR4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testicular Receptor 4 (TR4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testicular Receptor 4 (TR4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testicular Receptor 4 (TR4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testicular Receptor 4 (TR4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testicular Receptor 4 (TR4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testicular Receptor 4 (TR4) ELISA Kit Customized Service Offer
  1. "TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily."Mol. Endocrinol. 8:1667-1680(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily."Proc. Natl. Acad. Sci. U.S.A. 91:6040-6044(1994) [PubMed] [Europe PMC] [Abstract]
  3. "DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system."FEBS Lett. 582:2737-2744(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The orphan receptor TAK1 acts as a repressor of RAR-, RXR- and T3R-mediated signaling pathways."Biochem. Biophys. Res. Commun. 211:83-91(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4."J. Biol. Chem. 273:10948-10957(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor."J. Biol. Chem. 274:16198-16205(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor."J. Biol. Chem. 275:2763-2770(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation."J. Biol. Chem. 278:7709-7717(2003) [PubMed] [Europe PMC] [Abstract]
  11. "The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription."Genes Dev. 21:2832-2844(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Oxidative stress stimulates testicular orphan receptor 4 through forkhead transcription factor forkhead box O3a."Endocrinology 149:3490-3499(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "NLRP10 enhances Shigella-induced pro-inflammatory responses."Cell. Microbiol. 14:1568-1583(2012) [PubMed] [Europe PMC] [Abstract]