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3',5'-Bisphosphate Nucleotidase 1 (BPNT1)

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PIP; BPntase; Bisphosphate 3-Prime-Nucleotidase; Bisphosphate 3'-nucleotidase 1; PAP-inositol 1,4-phosphatase

3',5'-Bisphosphate Nucleotidase 1 (BPNT1)
CCC D940
HGNC 1096
MGI 1338800
PubMed 10660045
RGD 621833
UniProt O95861
At subtherapeutic concentrations, lithium, a major drug used to treat manic depression, inhibits members of a magnesium-dependent phosphomonoesterase family. Fructose 1,6-bisphosphatase, inositol monophosphatase, and inositol polyphosphate 1-phosphatase (1ptase), members of this family, contain a conserved motif involved in metal/lithium binding and catalysis.BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD940Hu01 Recombinant 3',5'-Bisphosphate Nucleotidase 1 (BPNT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD940Hu01 Polyclonal Antibody to 3',5'-Bisphosphate Nucleotidase 1 (BPNT1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for 3',5'-Bisphosphate Nucleotidase 1 (BPNT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for 3',5'-Bisphosphate Nucleotidase 1 (BPNT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD940Mu01 Recombinant 3',5'-Bisphosphate Nucleotidase 1 (BPNT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD940Mu01 Polyclonal Antibody to 3',5'-Bisphosphate Nucleotidase 1 (BPNT1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for 3',5'-Bisphosphate Nucleotidase 1 (BPNT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for 3',5'-Bisphosphate Nucleotidase 1 (BPNT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 3',5'-Bisphosphate Nucleotidase 1 (BPNT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 3',5'-Bisphosphate Nucleotidase 1 (BPNT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 3',5'-Bisphosphate Nucleotidase 1 (BPNT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 3',5'-Bisphosphate Nucleotidase 1 (BPNT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for 3',5'-Bisphosphate Nucleotidase 1 (BPNT1) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate."J. Biol. Chem. 274:13619-13628(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Human 3'(2'), 5'-bisphosphate nucleotidase 1 (BPNT1) in complex with AMP, PO4 and magnesium."Submitted (APR-2009) to the PDB data bank