Dipeptidyl Peptidase 3 (DPP3)
[Edit]DPPIII; Dipeptidylpeptidase 3; Enkephalinase B; Dipeptidyl arylamidase III; Dipeptidyl aminopeptidase III
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Dipeptidyl-peptidase 3 is a protein that is a member of the S9B family in clan SC of the serine proteases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins.
Increased activity of this protein is associated with endometrial and ovarian cancers. Alternate transcriptional splice variants have been characterized. DPP3 shows zinc-dependent metalloprotease activity and contains a conserved HELLGH motif with similarity to the zincin HExxH consensus motif. the molecular mass of full-length DPP3 is 82.5 kD; by SDS-PAGE, the apparent molecular mass is 81.2 kD.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPD907Hu01 | Recombinant Dipeptidyl Peptidase 3 (DPP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAD907Hu01 | Polyclonal Antibody to Dipeptidyl Peptidase 3 (DPP3) | WB; IHC |
Assay Kits | n/a | CLIA Kit for Dipeptidyl Peptidase 3 (DPP3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Dipeptidyl Peptidase 3 (DPP3) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPD907Mu01 | Recombinant Dipeptidyl Peptidase 3 (DPP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAD907Mu01 | Polyclonal Antibody to Dipeptidyl Peptidase 3 (DPP3) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Dipeptidyl Peptidase 3 (DPP3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Dipeptidyl Peptidase 3 (DPP3) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Dipeptidyl Peptidase 3 (DPP3) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Dipeptidyl Peptidase 3 (DPP3) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Dipeptidyl Peptidase 3 (DPP3) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Dipeptidyl Peptidase 3 (DPP3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Dipeptidyl Peptidase 3 (DPP3) | ELISA Kit Customized Service Offer |
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Dipeptidyl peptidase III is a zinc metallo-exopeptidase. Molecular cloning and expression."Biochem. J. 329:275-282(1998) [PubMed] [Europe PMC] [Abstract]
- "Human and rat dipeptidyl peptidase III: biochemical and mass spectrometric arguments for similarities and differences."Biol. Chem. 381:1233-1243(2000) [PubMed] [Europe PMC] [Abstract]
- "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
- "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III."Proc. Natl. Acad. Sci. U.S.A. 109:6525-6530(2012) [PubMed] [Europe PMC] [Abstract]