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Phospholipase C Delta 3 (PLCd3)

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PLC-delta-3; Phosphoinositide phospholipase C-delta-3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

Phospholipase C Delta 3 (PLCd3)
CCC D838
HGNC 9061
MGI 107451
PubMed 10702670
RGD 1310903
UniProt Q8N3E9
Wiki PLCD3
PLCD3 belongs to a large family of enzymes that catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate the second messengers Ins(1,4,5)P3 and diacylglycerol, which mediate a wide variety of cellular stimuli.PLCd3 encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD838Hu01 Recombinant Phospholipase C Delta 3 (PLCd3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD838Hu01 Polyclonal Antibody to Phospholipase C Delta 3 (PLCd3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Phospholipase C Delta 3 (PLCd3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase C Delta 3 (PLCd3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phospholipase C Delta 3 (PLCd3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phospholipase C Delta 3 (PLCd3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phospholipase C Delta 3 (PLCd3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phospholipase C Delta 3 (PLCd3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase C Delta 3 (PLCd3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phospholipase C Delta 3 (PLCd3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phospholipase C Delta 3 (PLCd3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phospholipase C Delta 3 (PLCd3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phospholipase C Delta 3 (PLCd3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase C Delta 3 (PLCd3) ELISA Kit Customized Service Offer
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  9. "Phospholipase C-delta3 binds with high specificity to phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in bilayer membranes."Eur. J. Biochem. 262:291-298(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Downregulation of phospholipase C delta3 by cAMP and calcium."Biochem. Biophys. Res. Commun. 286:274-280(2001) [PubMed] [Europe PMC] [Abstract]
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  12. "Expression of phospholipases A2 and C in human corneal epithelial cells."Invest. Ophthalmol. Vis. Sci. 45:3997-4003(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Phospholipase C isoforms are localized at the cleavage furrow during cytokinesis."J. Biochem. 140:785-791(2006) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]