≡

Small Proline Rich Protein 1B (SPRR1B)

[Edit]

SPRR1; GADD33; SPR-IB; 14.9 kDa pancornulin; Cornifin-B

Small Proline Rich Protein 1B (SPRR1B)
CCC D803
HGNC 11260
MGI 106659
PubMed 18172072
RGD 1587862
UniProt P22528
Wiki SPRR1B
All SPRR genes are closely linked within a 300-kb DNA segment on 1q21-q22.Marvin et al. (1992) characterized a cDNA clone corresponding to mRNA abundantly expressed in differentiating squamous cells originally isolated from a rabbit squamous cell library. Small Proline Rich Protein 1B is a 14-kD protein that appears to function as a component of the crosslinked envelope in squamous differentiating cells. Called cornifin, the protein has a high content of proline (31%), glutamine (20%), and cysteine (11%) and contains 13 repeats of an octapeptide (consensus sequence, EPCQPKVP) at its C terminus. In situ hybridization analysis showed that the mRNA is restricted to the suprabasal layers of the epidermis. Crosslinking of the protein appears to be mediated by transglutaminase type I.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Proline Rich Protein 1B (SPRR1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Proline Rich Protein 1B (SPRR1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Proline Rich Protein 1B (SPRR1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Proline Rich Protein 1B (SPRR1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Proline Rich Protein 1B (SPRR1B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Proline Rich Protein 1B (SPRR1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Proline Rich Protein 1B (SPRR1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Proline Rich Protein 1B (SPRR1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Proline Rich Protein 1B (SPRR1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Proline Rich Protein 1B (SPRR1B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Proline Rich Protein 1B (SPRR1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Proline Rich Protein 1B (SPRR1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Proline Rich Protein 1B (SPRR1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Proline Rich Protein 1B (SPRR1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Proline Rich Protein 1B (SPRR1B) ELISA Kit Customized Service Offer
  1. "Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes."Mol. Cell. Biol. 8:2195-2203(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and characterization of the human spr1 gene and its regulation of expression by phorbol ester and cyclic AMP."J. Biol. Chem. 268:10977-10982(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation."J. Invest. Dermatol. 104:204-210(1995) [PubMed] [Europe PMC] [Abstract]