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Topoisomerase III (TOP3)

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TOP3A; DNA topoisomerase III alpha

Topoisomerase III (TOP3)
CCC D800
HGNC 11992
MGI 1197527
PubMed 16164551
UniProt Q13472
Wiki TOP3A
DNA topoisomerase 3-alpha is ana DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells.High expression is found in testis, heart, skeletal muscle and pancreas. Reduces the number of supercoils in a highly negatively supercoiled DNA. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD800Hu01 Recombinant Topoisomerase III (TOP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD800Hu01 Polyclonal Antibody to Topoisomerase III (TOP3) WB; IHC
MAD800Hu21 Monoclonal Antibody to Topoisomerase III (TOP3) WB; IHC; ICC; IP.
Assay Kits SED800Hu ELISA Kit for Topoisomerase III (TOP3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Topoisomerase III (TOP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Topoisomerase III (TOP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Topoisomerase III (TOP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Topoisomerase III (TOP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Topoisomerase III (TOP3) ELISA Kit Customized Service Offer
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  2. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity."EMBO J. 24:1465-1476(2005) [PubMed] [Europe PMC] [Abstract]
  7. "RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability."Genes Dev. 22:2843-2855(2008) [PubMed] [Europe PMC] [Abstract]
  8. "BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome."Genes Dev. 22:2856-2868(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1."J. Biol. Chem. 285:21426-21436(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair."Proc. Natl. Acad. Sci. U.S.A. 110:10646-10651(2013) [PubMed] [Europe PMC] [Abstract]