Protein Disulfide Isomerase A4 (PDIA4)
[Edit]PDI-A4; ERP70; ERP72; Protein Disulfide Isomerase-Associated 4; Endoplasmic reticulum resident protein 70
Protein Disulfide Isomerase A4is an enzyme in the endoplasmic reticulum in eukaryotes or periplasmic space of prokaryotes that catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. This allows proteins to quickly find the correct arrangement of disulfide bonds in their fully-folded state, and therefore the enzyme acts to catalyze protein folding.
The reduced (dithiol) form of PDI is able to catalyse a reduction of mispaired thiol residues of a particular substrate, acting as an isomerase. Therefore, PDI is capable of catalyzing the posttranslational modification disulfide exchange. Such exchange reactions can occur intramolecularly, leading to the rearrangement of disulfide bonds in a single protein.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPD774Hu01 | Recombinant Protein Disulfide Isomerase A4 (PDIA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAD774Hu01 | Polyclonal Antibody to Protein Disulfide Isomerase A4 (PDIA4) | WB,IHC |
MAD774Hu21 | Monoclonal Antibody to Protein Disulfide Isomerase A4 (PDIA4) | WB; IHC; ICC; IP. | |
Assay Kits | SED774Hu | ELISA Kit for Protein Disulfide Isomerase A4 (PDIA4) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPD774Mu01 | Recombinant Protein Disulfide Isomerase A4 (PDIA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPD774Mu02 | Recombinant Protein Disulfide Isomerase A4 (PDIA4) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAD774Mu01 | Polyclonal Antibody to Protein Disulfide Isomerase A4 (PDIA4) | WB; IHC; ICC; IP. |
PAD774Mu02 | Polyclonal Antibody to Protein Disulfide Isomerase A4 (PDIA4) | WB; IHC; ICC; IP. | |
Assay Kits | SED774Mu | ELISA Kit for Protein Disulfide Isomerase A4 (PDIA4) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Protein Disulfide Isomerase A4 (PDIA4) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Protein Disulfide Isomerase A4 (PDIA4) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Protein Disulfide Isomerase A4 (PDIA4) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Protein Disulfide Isomerase A4 (PDIA4) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Protein Disulfide Isomerase A4 (PDIA4) | ELISA Kit Customized Service Offer |
- "Human deoxycytidine kinase. Sequence of cDNA clones and analysis of expression in cell lines with and without enzyme activity."J. Biol. Chem. 264:14762-14768(1989) [PubMed] [Europe PMC] [Abstract]
- ErratumJ. Biol. Chem. 266:5353-5353(1991) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins."Mol. Biol. Cell 13:4456-4469(2002) [PubMed] [Europe PMC] [Abstract]
- "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."J. Proteome Res. 2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
- "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
- "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]