High Mobility Group Protein 20B (HMG20B)
[Edit]BRAF35; HMGX2; SMARCE1r; SOXL; Sox-like transcriptional factor; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
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High mobility group (HMG) proteins are nonhistone chromosomal proteins that contain a conserved DNA-binding domain called the HMG box.BRAF35 protein contains a nonspecific DNA-binding HMG domain and a kinesin-like coiled-coil domain. The only protein with structural domains similar to those of BRAF35 was BAF57, a subunit of the SWI/SNF complex. In situ hybridization showed that similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos were highest in proliferating tissues with high mitotic index. Strikingly, nuclear staining revealed a close association of the BRAF35-BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation. Antibody microinjection experiments suggested a role for the BRCA2-BRAF35 complex in modulation of cell cycle progression.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD771Hu01 | Recombinant High Mobility Group Protein 20B (HMG20B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAD771Hu01 | Polyclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for High Mobility Group Protein 20B (HMG20B) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for High Mobility Group Protein 20B (HMG20B) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD771Mu01 | Recombinant High Mobility Group Protein 20B (HMG20B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAD771Mu01 | Polyclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for High Mobility Group Protein 20B (HMG20B) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for High Mobility Group Protein 20B (HMG20B) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant High Mobility Group Protein 20B (HMG20B) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to High Mobility Group Protein 20B (HMG20B) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to High Mobility Group Protein 20B (HMG20B) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for High Mobility Group Protein 20B (HMG20B) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for High Mobility Group Protein 20B (HMG20B) | ELISA Kit Customized Service Offer |
- "HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression."Cytogenet. Cell Genet. 88:62-67(2000) [PubMed] [Europe PMC] [Abstract]
- "A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression."Cell 104:247-257(2001) [PubMed] [Europe PMC] [Abstract]
- "Characterization of human SMARCE1r high-mobility-group protein."Biochim. Biophys. Acta 1574:269-276(2002) [PubMed] [Europe PMC] [Abstract]
- "Cloning a cDNA encoding an alternatively spliced protein of BRCA2-associated factor 35."Biochem. Biophys. Res. Commun. 295:129-135(2002) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes."Proc. Natl. Acad. Sci. U.S.A. 99:7420-7425(2002) [PubMed] [Europe PMC] [Abstract]
- "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes."J. Biol. Chem. 278:7234-7239(2003) [PubMed] [Europe PMC] [Abstract]