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Apolipoprotein L (APOL1)

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Apo-L; APOL; APOL-I

Apolipoprotein L (APOL1)
CCC D741
HGNC 618
PubMed 22257798
UniProt O14791
Wiki APOL1
Apolipoprotein L (APOL) proteins belong to the high density lipoprotein family, which plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. The 6 APOL genes are clustered on chromosome 22q12.3.
The cDNA encodes a 383-amino acid polypeptide that includes a 12-amino acid secretory signal peptide. Northern blot analysis detected a 1.3-kb APOL transcript in the pancreas but not in any other human tissues. Affinity immunosorption showed that APOL is not free in the plasma, but is associated with lipoproteins containing APOA1. APOL was found in high density lipoprotein fractions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD741Hu01 Recombinant Apolipoprotein L (APOL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD741Hu01 Polyclonal Antibody to Apolipoprotein L (APOL1) WB; IHC
MAD741Hu21 Monoclonal Antibody to Apolipoprotein L (APOL1) WB; IHC; ICC; IP.
Assay Kits SED741Hu ELISA Kit for Apolipoprotein L (APOL1) Enzyme-linked immunosorbent assay for Antigen Detection.
HED741Hu High Sensitive ELISA Kit for Apolipoprotein L (APOL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apolipoprotein L (APOL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apolipoprotein L (APOL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apolipoprotein L (APOL1) Polyclonal Antibody Customized Service Offer
Assay Kits SED741Mu ELISA Kit for Apolipoprotein L (APOL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apolipoprotein L (APOL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apolipoprotein L (APOL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apolipoprotein L (APOL1) Polyclonal Antibody Customized Service Offer
Assay Kits SED741Ra ELISA Kit for Apolipoprotein L (APOL1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L."J. Biol. Chem. 272:25576-25582(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene."J. Lipid Res. 42:620-630(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution."Genomics 74:71-78(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue."Genomics 79:539-546(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene."Hum. Genet. 128:345-350(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Association of trypanolytic ApoL1 variants with kidney disease in African Americans."Science 329:841-845(2010) [PubMed] [Europe PMC] [Abstract]