Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3)

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CD158Z; KIRC1; KIR3DL7; KIR44; CD158 antigen-like family member Z; Killer cell inhibitory receptor 1

Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3)
KIR3DL3 content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD714Hu01 Recombinant Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD714Hu01 Polyclonal Antibody to Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3) WB; IHC; ICC; IP.
LAD714Hu81 FITC-Linked Polyclonal Antibody to Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3) WB; IHC; ICC; IF.
LAD714Hu71 Biotin-Linked Polyclonal Antibody to Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3) ELISA Kit Customized Service Offer
  1. "Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex."Eur. J. Immunol. 28:3959-3967(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158)."Immunol. Rev. 181:223-233(2001) [PubMed] [Europe PMC] [Abstract].
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "KIR3DL3 allelic diversity: six new alleles exhibit both conservative and non-conservative substitutions."Tissue Antigens 67:277-283(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Seventeen novel alleles add to the already extensive KIR3DL3 diversity."Tissue Antigens 70:449-454(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Natural killer immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations."Genes Immun. 3:86-95(2002) [PubMed] [Europe PMC] [Abstract]