Killer Cell Immunoglobulin Like Receptor 2DS5 (KIR2DS5)
[Edit]CD158G; Nkat9; CD158 antigen-like family member G; MHC class I NK cell receptor; Natural killer-associated transcript 9
![Killer Cell Immunoglobulin Like Receptor 2DS5 (KIR2DS5)](/upload/item/img/Killer-Cell-Immunoglobulin-Like-Receptor-2DS5-(KIR2DS5)-93713.jpg)
The existence of human inhibitory natural killer (NK) cell receptors for MHC class I molecules (now designated killer cell Ig-like receptors, or KIRs), was inferred from the observation that NK cells killed HLA class I-deficient cell lines. Dohring et al. (1996) identified KIR2DS5, which they termed NKAT9. The cDNA encodes a deduced 304-amino acid protein. Sequence analysis revealed a structure similar to that described for KIR2DS2 , with an extracellular domain containing 2 Ig-like domains. The transmembrane region contains a charged lysine residue, and the cytoplasmic tail has only 39 amino acids with no ITIM (immunoreceptor tyrosine-based inhibitory motif). KIRs with short cytoplasmic tails are associated with NK cell triggering rather than inhibition. Wende et al. (1999) mapped the KIR2DS5 gene to chromosome 19q13.4 by long-range restriction analysis of YAC and PAC contigs.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Killer Cell Immunoglobulin Like Receptor 2DS5 (KIR2DS5) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DS5 (KIR2DS5) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DS5 (KIR2DS5) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Killer Cell Immunoglobulin Like Receptor 2DS5 (KIR2DS5) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Killer Cell Immunoglobulin Like Receptor 2DS5 (KIR2DS5) | ELISA Kit Customized Service Offer |
- "Alternatively spliced forms of human killer inhibitory receptors."Immunogenetics 44:227-230(1996) [PubMed] [Europe PMC] [Abstract]