Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1)

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CD158H; EB6ActI; EB6ActII; CD158 antigen-like family member H; MHC class I NK cell receptor Eb6 ActI

Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1)
The KIR2DS1 cDNA encodes a deduced 304-amino acid transmembrane protein. Sequence analysis revealed that the extracellular domain of KIR2D p50 receptors is similar to that of KIR2D p58 receptors; however, in the transmembrane region, there is a charged lysine residue consistently encoded by AAA, and the cytoplasmic tail has only 39 amino acids with no ITIM (immunoreceptor tyrosine-based inhibitory motif). KIRs with short cytoplasmic tails are associated with NK cell triggering rather than inhibition. Immunoprecipitation and Western blot analyses of KIR2DS1 expressed in COS cells revealed a 50-kD protein. Flow cytometric analysis confirmed surface expression of KIR2DS1. Biassoni et al. (1996) pointed out that receptors with identical HLA-C allele specificity can mediate opposite functions owing to their different transmembrane/cytoplasmic regions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1) ELISA Kit Customized Service Offer
  1. "The human leukocyte antigen (HLA)-C-specific 'activatory' or 'inhibitory' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions."J. Exp. Med. 183:645-650(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Human diversity in killer cell inhibitory receptor genes."Immunity 7:753-763(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]