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Regulator Of G Protein Signaling 2 (RGS2)

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G0S8; GIG31; Cell growth-inhibiting gene 31 protein; G0/G1 switch regulatory protein 8

Regulator Of G Protein Signaling 2 (RGS2)
CCC D702
HGNC 9998
MGI 1098271
PubMed 18316676
RGD 621665
UniProt P41220
Wiki RGS2
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms.
Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis.Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
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Assay Kits SED702Hu ELISA Kit for Regulator Of G Protein Signaling 2 (RGS2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulator Of G Protein Signaling 2 (RGS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulator Of G Protein Signaling 2 (RGS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulator Of G Protein Signaling 2 (RGS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulator Of G Protein Signaling 2 (RGS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulator Of G Protein Signaling 2 (RGS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulator Of G Protein Signaling 2 (RGS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulator Of G Protein Signaling 2 (RGS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulator Of G Protein Signaling 2 (RGS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulator Of G Protein Signaling 2 (RGS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulator Of G Protein Signaling 2 (RGS2) ELISA Kit Customized Service Offer
  1. "A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells."DNA Cell Biol. 13:125-147(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Mechanisms governing subcellular localization and function of human RGS2."J. Biol. Chem. 276:14195-14203(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins."Mol. Pharmacol. 73:1-11(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31."Leukemia 9:1291-1298(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling."J. Biol. Chem. 276:5438-5444(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure."Nat. Med. 9:1506-1512(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Translational control by RGS2."J. Cell Biol. 186:755-765(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits."Proc. Natl. Acad. Sci. U.S.A. 105:6457-6462(2008) [PubMed] [Europe PMC] [Abstract]