≡

Sterol-O-Acyltransferase 1 (SOAT1)

[Edit]

ACAT1; ACAT; ACACT; SOAT; STAT; Acyl-Coenzyme A:Cholesterol Acyltransferase; Cholesterol acyltransferase 1

Sterol-O-Acyltransferase 1 (SOAT1)
CCC D695
HGNC 11177
MGI 104665
PubMed 21239516
RGD 621641
UniProt P35610
Wiki SOAT1
Acyl-coenzyme A:cholesterol acyltransferase (ACACT; EC 2.3.1.26) is an intracellular protein located in the endoplasmic reticulum that forms cholesterol esters from cholesterol. Accumulation of cholesterol esters as cytoplasmic lipid droplets within macrophages and smooth muscle cells is a characteristic feature of the early stages of atherosclerotic plaques
A deletion of ARE2 reduced the sterol ester levels to approximately 25% of normal levels, whereas disruption of ARE1 did not affect sterol ester biosynthesis. Deletion of both genes resulted in a viable cell with undetectable esterified sterol. With the use of a consensus sequence to the yeast and human genes, an additional member of the SOAT gene family was identified in humans.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sterol-O-Acyltransferase 1 (SOAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sterol-O-Acyltransferase 1 (SOAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sterol-O-Acyltransferase 1 (SOAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sterol-O-Acyltransferase 1 (SOAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sterol-O-Acyltransferase 1 (SOAT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sterol-O-Acyltransferase 1 (SOAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sterol-O-Acyltransferase 1 (SOAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sterol-O-Acyltransferase 1 (SOAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sterol-O-Acyltransferase 1 (SOAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sterol-O-Acyltransferase 1 (SOAT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sterol-O-Acyltransferase 1 (SOAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sterol-O-Acyltransferase 1 (SOAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sterol-O-Acyltransferase 1 (SOAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sterol-O-Acyltransferase 1 (SOAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sterol-O-Acyltransferase 1 (SOAT1) ELISA Kit Customized Service Offer
  1. "Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells."J. Biol. Chem. 268:20747-20755(1993) [PubMed] [Europe PMC] [Abstract]
  2. , Submitted (MAY-1999) to UniProtKB
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains."J. Biol. Chem. 274:23276-23285(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain."J. Biol. Chem. 280:37814-37826(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of putative active site residues of ACAT enzymes."J. Lipid Res. 49:1770-1781(2008) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "The UBIAD1 prenyltransferase links menaquione-4 synthesis to cholesterol metabolic enzymes."Hum. Mutat. 34:317-329(2013) [PubMed] [Europe PMC] [Abstract]