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Coenzyme A Synthase (COASY)

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NBP; PPAT; DPCK; UKR1; pOV-2; DPCOAK; Phosphopantetheine adenylyltransferase; Dephospho-CoA pyrophosphorylase; Dephospho-CoA kinase; Dephosphocoenzyme A kinase

Coenzyme A Synthase (COASY)
CCC D668
HGNC 29932
MGI 1918993
PubMed 19482007
RGD 1549767
UniProt Q13057
Wiki COASY
COASY has been shown to interact with P70-S6 Kinase 1. COASY has also been implicated in PI3K signaling, as it was shown to interact with a regulatory subunit of PI3K.
Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain.Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. COASY is a bifunctional enzyme that catalyzes the 2 last steps in CoA synthesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD668Hu01 Recombinant Coenzyme A Synthase (COASY) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Coenzyme A Synthase (COASY) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coenzyme A Synthase (COASY) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coenzyme A Synthase (COASY) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coenzyme A Synthase (COASY) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD668Mu01 Recombinant Coenzyme A Synthase (COASY) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD668Mu01 Polyclonal Antibody to Coenzyme A Synthase (COASY) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Coenzyme A Synthase (COASY) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coenzyme A Synthase (COASY) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coenzyme A Synthase (COASY) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coenzyme A Synthase (COASY) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coenzyme A Synthase (COASY) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coenzyme A Synthase (COASY) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coenzyme A Synthase (COASY) ELISA Kit Customized Service Offer
  1. "Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics."J. Biol. Chem. 277:21431-21439(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase)."Biochem. J. 365:13-18(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A 100-kb physical and transcriptional map around the EDH17B2 gene: identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase."Hum. Genet. 96:532-538(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a novel CoA synthase isoform, which is primarily expressed in the brain."Biochem. Biophys. Res. Commun. 341:995-1000(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Exome sequence reveals mutations in CoA synthase as a cause of neurodegeneration with brain iron accumulation." Am. J. Hum. Genet. 94:11-22(2014) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]