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Acetyl Coenzyme A Acetyltransferase 2 (ACAT2)

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ACTL; Acetoacetyl Coenzyme A Thiolase; Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase

Acetyl Coenzyme A Acetyltransferase 2 (ACAT2)
CCC D665
HGNC 94
MGI 87871
PubMed 15486928
RGD 1359366
UniProt Q9BWD1
Wiki ACAT2
ACAT2 is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation.As the human TCP1 gene had been assigned to 6q25-q27 by study of somatic cell hybrids and by in situ hybridization, the ACAT2 gene was suspected to be localized to the same chromosome region. Retention of this close linkage during mammalian evolution suggests the possibility of some functional significance. Transcription of both DNA strands at a given locus is common in prokaryotic and viral systems. For examples of overlapping transcriptional units in humans.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD665Hu01 Recombinant Acetyl Coenzyme A Acetyltransferase 2 (ACAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD665Hu01 Polyclonal Antibody to Acetyl Coenzyme A Acetyltransferase 2 (ACAT2) WB; IHC; ICC; IP.
MAD665Hu21 Monoclonal Antibody to Acetyl Coenzyme A Acetyltransferase 2 (ACAT2) WB; IHC; ICC; IP.
Assay Kits SED665Hu ELISA Kit for Acetyl Coenzyme A Acetyltransferase 2 (ACAT2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD665Mu01 Recombinant Acetyl Coenzyme A Acetyltransferase 2 (ACAT2) Positive Control; Immunogen; SDS-PAGE; WB.
RPD665Mu02 Recombinant Acetyl Coenzyme A Acetyltransferase 2 (ACAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD665Mu01 Polyclonal Antibody to Acetyl Coenzyme A Acetyltransferase 2 (ACAT2) WB; IHC; ICC; IP.
PAD665Mu02 Polyclonal Antibody to Acetyl Coenzyme A Acetyltransferase 2 (ACAT2) WB; IHC; ICC; IP.
Assay Kits SED665Mu ELISA Kit for Acetyl Coenzyme A Acetyltransferase 2 (ACAT2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acetyl Coenzyme A Acetyltransferase 2 (ACAT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acetyl Coenzyme A Acetyltransferase 2 (ACAT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acetyl Coenzyme A Acetyltransferase 2 (ACAT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acetyl Coenzyme A Acetyltransferase 2 (ACAT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acetyl Coenzyme A Acetyltransferase 2 (ACAT2) ELISA Kit Customized Service Offer
  1. "Molecular cloning and nucleotide sequence of complementary DNA for human hepatic cytosolic acetoacetyl-coenzyme A thiolase."Biochem. Biophys. Res. Commun. 201:478-485(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (DEC-2008) to UniProtKB
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "High resolution crystal structures of human cytosolic thiolase (CT): a comparison of the active sites of human CT, bacterial thiolase, and bacterial KAS I."J. Mol. Biol. 347:189-201(2005) [PubMed] [Europe PMC] [Abstract]