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Acyl Coenzyme A Dehydrogenase, C2-To-C3 Short Chain (ACADS)

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SCAD; ACAD3; Butyryl-CoA dehydrogenase; Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Acyl Coenzyme A Dehydrogenase, C2-To-C3 Short Chain (ACADS)
CCC D663
HGNC 90
MGI 87868
PubMed 18523805
RGD 620514
UniProt P16219
Wiki ACADS
ACADS is a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with Short Chain Acyl-CoA Dehydrogenase Deficiency.
Like the other 4 enzymes belonging to the acyl-CoA dehydrogenase family of genes, SCAD is a tetrameric mitochondrial flavoprotein. It is synthesized as a 44-kD precursor, transported into mitochondria, and proteolytically processed to its 41-kD mature form. Comparison of SCAD and MCAD showed a high degree of homology, suggesting that these enzymes evolved from a common ancestral gene and belong to a gene family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD663Hu01 Recombinant Acyl Coenzyme A Dehydrogenase, C2-To-C3 Short Chain (ACADS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD663Hu01 Polyclonal Antibody to Acyl Coenzyme A Dehydrogenase, C2-To-C3 Short Chain (ACADS) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Acyl Coenzyme A Dehydrogenase, C2-To-C3 Short Chain (ACADS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acyl Coenzyme A Dehydrogenase, C2-To-C3 Short Chain (ACADS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD663Mu01 Recombinant Acyl Coenzyme A Dehydrogenase, C2-To-C3 Short Chain (ACADS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD663Mu01 Polyclonal Antibody to Acyl Coenzyme A Dehydrogenase, C2-To-C3 Short Chain (ACADS) WB; IHC; ICC; IP.
Assay Kits SED663Mu ELISA Kit for Acyl Coenzyme A Dehydrogenase, C2-To-C3 Short Chain (ACADS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acyl Coenzyme A Dehydrogenase, C2-To-C3 Short Chain (ACADS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acyl Coenzyme A Dehydrogenase, C2-To-C3 Short Chain (ACADS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acyl Coenzyme A Dehydrogenase, C2-To-C3 Short Chain (ACADS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acyl Coenzyme A Dehydrogenase, C2-To-C3 Short Chain (ACADS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acyl Coenzyme A Dehydrogenase, C2-To-C3 Short Chain (ACADS) ELISA Kit Customized Service Offer
  1. "Molecular cloning and nucleotide sequence of complementary DNAs encoding human short chain acyl-coenzyme A dehydrogenase and the study of the molecular basis of human short chain acyl-coenzyme A dehydrogenase deficiency."J. Clin. Invest. 83:1605-1613(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Structural organization of the human short-chain acyl-CoA dehydrogenase gene."Mamm. Genome 8:922-926(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human liver protein map: a reference database established by microsequencing and gel comparison."Electrophoresis 13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of human RAB14."Submitted (FEB-2009) to the PDB data bank
  8. "Identification of two variant short chain acyl-coenzyme A dehydrogenase alleles, each containing a different point mutation in a patient with short chain acyl-coenzyme A dehydrogenase deficiency."J. Clin. Invest. 85:1575-1582(1990) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of four new mutations in the short-chain acyl-CoA dehydrogenase (SCAD) gene in two patients: one of the variant alleles, 511C-->T, is present at an unexpectedly high frequency in the general population, as was the case for 625G-->A, together conferring susceptibility to ethylmalonic aciduria."Hum. Mol. Genet. 7:619-627(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Role of common gene variations in the molecular pathogenesis of short-chain acyl-CoA dehydrogenase deficiency."Pediatr. Res. 49:18-23(2001) [PubMed] [Europe PMC] [Abstract]