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Acetyl Coenzyme A Carboxylase Beta (ACACb)

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ACC2; ACCB; Biotin carboxylase

Acetyl Coenzyme A Carboxylase Beta (ACACb)
CCC D660
HGNC 85
MGI 2140940
PubMed 23460794
RGD 620500
UniProt O00763
Wiki ACACB
ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms.The predicted 2,458-amino acid ACC-beta protein contains a unique, approximately 200-amino acid sequence at its N terminus that may be related to the role of ACC-beta in controlling carnitine palmitoyltransferase I activity and fatty acid oxidation by mitochondria. Excluding this unique N-terminal sequence, ACC-alpha and -beta share about 75% amino acid identity. All of the functional domains of ACC are found in homologous regions of the proteins. The approximately 10-kb ACC-beta mRNA was primarily expressed in heart and skeletal muscle tissues. In contrast, ACC-alpha mRNA was detected in all tissues tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD660Hu01 Recombinant Acetyl Coenzyme A Carboxylase Beta (ACACb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD660Hu01 Polyclonal Antibody to Acetyl Coenzyme A Carboxylase Beta (ACACb) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Acetyl Coenzyme A Carboxylase Beta (ACACb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acetyl Coenzyme A Carboxylase Beta (ACACb) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD660Mu01 Recombinant Acetyl Coenzyme A Carboxylase Beta (ACACb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Acetyl Coenzyme A Carboxylase Beta (ACACb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acetyl Coenzyme A Carboxylase Beta (ACACb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acetyl Coenzyme A Carboxylase Beta (ACACb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acetyl Coenzyme A Carboxylase Beta (ACACb) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acetyl Coenzyme A Carboxylase Beta (ACACb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acetyl Coenzyme A Carboxylase Beta (ACACb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acetyl Coenzyme A Carboxylase Beta (ACACb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acetyl Coenzyme A Carboxylase Beta (ACACb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acetyl Coenzyme A Carboxylase Beta (ACACb) ELISA Kit Customized Service Offer
  1. "Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms."J. Biol. Chem. 272:10669-10677(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes."Protein Expr. Purif. 51:11-21(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of a second human acetyl-CoA carboxylase gene."Biochem. J. 316:915-922(1996) [PubMed] [Europe PMC] [Abstract]
  5. "The subcellular localization of acetyl-CoA carboxylase 2."Proc. Natl. Acad. Sci. U.S.A. 97:1444-1449(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle."Am. J. Physiol. 284:E813-E822(2003) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "ACC2 is expressed at high levels in human white adipose and has an isoform with a novel N-terminus."PLoS ONE 4:E4369-E4369(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of Spot 14, a modulator of fatty acid synthesis."Proc. Natl. Acad. Sci. U.S.A. 107:18820-18825(2010) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the biotin carboxylase domain of human acetyl-CoA carboxylase 2."Proteins 70:268-272(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of RSGI RUH-053, an apo-biotin carboxy carrier protein from human transcarboxylase."Submitted (OCT-2006) to the PDB data bank
  13. "Core signaling pathways in human pancreatic cancers revealed by global genomic analyses." Science 321:1801-1806(2008) [PubMed] [Europe PMC] [Abstract]