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Protein Tyrosine Phosphatase, Non Receptor Type 14 (PTPN14)

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PEZ; PTP36; PTPD2; Protein-tyrosine phosphatase pez

Protein Tyrosine Phosphatase, Non Receptor Type 14 (PTPN14)
CCC D594
HGNC 9647
MGI 102467
PubMed 22948661
RGD 1307885
UniProt Q15678
Wiki PTPN14
Tyrosine-protein phosphatase non-receptor type 14 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined.Expressed in a variety of human tissues including kidney, skeletal muscle, lung and placenta.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD594Hu01 Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 14 (PTPN14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 14 (PTPN14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 14 (PTPN14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 14 (PTPN14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 14 (PTPN14) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 14 (PTPN14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 14 (PTPN14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 14 (PTPN14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 14 (PTPN14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 14 (PTPN14) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD594Ra01 Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 14 (PTPN14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD594Ra01 Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 14 (PTPN14) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 14 (PTPN14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 14 (PTPN14) ELISA Kit Customized Service Offer
  1. "Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains."Biochem. Biophys. Res. Commun. 209:959-965(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation."J. Cell Sci. 113:3117-3123(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin."Mol. Biol. Cell 14:2520-2529(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The protein tyrosine phosphatase Pez regulates TGFbeta, epithelial-mesenchymal transition, and organ development."J. Cell Biol. 178:1223-1235(2007) [PubMed] [Europe PMC] [Abstract]
  7. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans."Am. J. Hum. Genet. 87:436-444(2010) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "PTPN14 is required for the density-dependent control of YAP1."Genes Dev. 26:1959-1971(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia." Nat. Commun. 3:616-616(2012) [PubMed] [Europe PMC] [Abstract]
  14. "PTPN14 interacts with and negatively regulates the oncogenic function of YAP."Oncogene 32:1266-1273(2013) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution."Proteins 63:1132-1136(2006) [PubMed] [Europe PMC] [Abstract]
  16. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]