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Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12)

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PTP-PEST; PTPG1; Protein-tyrosine phosphatase G1

Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12)
CCC D592
HGNC 9645
MGI 104673
PubMed 24475046
RGD 620894
UniProt Q05209
Wiki PTPN12
Tyrosine-protein phosphatase non-receptor type 12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD592Hu01 Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD592Hu01 Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD592Mu01 Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 12 (PTPN12) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a human cDNA encoding a novel putative cytoplasmic protein-tyrosine-phosphatase."Biochem. Biophys. Res. Commun. 189:1223-1230(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase."J. Biol. Chem. 268:6622-6628(1993) [PubMed] [Europe PMC] [Abstract]
  3. ErratumJ. Biol. Chem. 268:17650-17650(1993) [PubMed] [Europe PMC] [Abstract]
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  8. "Chromosomal localization of the protein tyrosine phosphatase G1 gene and characterization of the aberrant transcripts in human colon cancer cells."FEBS Lett. 339:222-228(1994) [PubMed] [Europe PMC] [Abstract]
  9. "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion."EMBO J. 17:7320-7336(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST."J. Biol. Chem. 281:38405-38417(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells."Am. J. Physiol. 292:C2288-C2296(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  20. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]