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Mitogen Activated Protein Kinase Kinase Kinase 15 (MAP3K15)

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ASK3; MEKK 15; Apoptosis signal-regulating kinase 3; MAPK/ERK kinase kinase 15

Mitogen Activated Protein Kinase Kinase Kinase 15 (MAP3K15)
CCC D575
HGNC 31689
MGI 2448588
UniProt Q6ZN16
Mitogen Activated Protein Kinase Kinase Kinase 15 (MAP3K15) contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-812, inhibited by phosphorylation at Ser-924 and Ser-994.
Perhaps the best characterized MAP3K are the members of the oncogenic RAF family (RAF1, BRAF, ARAF), which are effectors of mitogenic ras signaling and which activate the ERK1/2 (MAPK3/MAPK1) pathway, through activation of MEK1(MAP2K1) and MEK2(MAP2K2).MEKK1 activates MAPK8/JNK by phosphorylation of its activator SEK1(MAP2K4). MAP3K3 directly regulates the MAPK8/JNK and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway.MAP3K7(TAK1)participate in regulation of transcription by transforming growth factor-beta (TGF-beta).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 15 (MAP3K15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 15 (MAP3K15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 15 (MAP3K15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 15 (MAP3K15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 15 (MAP3K15) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 15 (MAP3K15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 15 (MAP3K15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 15 (MAP3K15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 15 (MAP3K15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 15 (MAP3K15) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  4. "ASK3, a novel member of the apoptosis signal-regulating kinase family, is essential for stress-induced cell death in HeLa cells."Biochem. Biophys. Res. Commun. 395:213-218(2010) [PubMed] [Europe PMC] [Abstract]
  5. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]