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Mitogen Activated Protein Kinase Kinase Kinase 7 (MAP3K7)

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TAK1; TGF1a; MEKK7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1

Mitogen Activated Protein Kinase Kinase Kinase 7 (MAP3K7)
CCC D567
HGNC 6859
MGI 1346877
PubMed 24036998
RGD 1309438
UniProt O43318
Wiki MAP3K7
Mitogen-activated protein kinase kinase kinase 7 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis.
In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Polyclonal Antibody Customized Service Offer
Assay Kits SED567Hu ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 (MAP3K7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 (MAP3K7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 (MAP3K7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 7 (MAP3K7) ELISA Kit Customized Service Offer
  1. "TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism."Biochem. Biophys. Res. Commun. 243:545-549(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1."Biochim. Biophys. Acta 1517:46-52(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3."J. Biol. Chem. 271:13675-13679(1996) [PubMed] [Europe PMC] [Abstract]
  7. "TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction."Science 272:1179-1182(1996) [PubMed] [Europe PMC] [Abstract]
  8. "TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase."J. Biol. Chem. 272:8141-8144(1997) [PubMed] [Europe PMC] [Abstract]
  9. "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway."Nature 398:252-256(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1."FEBS Lett. 474:141-145(2000) [PubMed] [Europe PMC] [Abstract]
  11. "TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop."J. Biol. Chem. 275:7359-7364(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Regulation of the TAK1 signaling pathway by protein phosphatase 2C."J. Biol. Chem. 276:5753-5759(2001) [PubMed] [Europe PMC] [Abstract]
  13. "TAK1 is a ubiquitin-dependent kinase of MKK and IKK."Nature 412:346-351(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol."Mol. Cell. Biol. 22:7158-7167(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Pellino2 activates the mitogen activated protein kinase pathway."FEBS Lett. 545:199-202(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein."J. Immunol. 171:1500-1506(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3."Mol. Biol. Cell 14:529-544(2003) [PubMed] [Europe PMC] [Abstract]
  18. "TAB3, a new binding partner of the protein kinase TAK1."Biochem. J. 378:27-34(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway."J. Biol. Chem. 280:25920-25927(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  21. "The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway."EMBO Rep. 7:838-844(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways."J. Biol. Chem. 281:28802-28810(2006) [PubMed] [Europe PMC] [Abstract]
  23. "Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway."J. Biol. Chem. 281:39891-39896(2006) [PubMed] [Europe PMC] [Abstract]
  24. "RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation."J. Biol. Chem. 282:16776-16782(2007) [PubMed] [Europe PMC] [Abstract]
  25. "Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses."J. Exp. Med. 204:1475-1485(2007) [PubMed] [Europe PMC] [Abstract]
  26. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  27. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  28. "The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner."Nat. Cell Biol. 10:1199-1207(2008) [PubMed] [Europe PMC] [Abstract]
  29. "Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein."PLoS ONE 3:E1660-E1660(2008) [PubMed] [Europe PMC] [Abstract]
  30. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  31. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  32. "WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway."Cell. Mol. Life Sci. 66:2573-2584(2009) [PubMed] [Europe PMC] [Abstract]
  33. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  34. "Direct activation of protein kinases by unanchored polyubiquitin chains."Nature 461:114-119(2009) [PubMed] [Europe PMC] [Abstract]
  35. "Ubiquitin-mediated activation of TAK1 and IKK."Oncogene 26:3214-3226(2007) [PubMed] [Europe PMC] [Abstract]
  36. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  37. "The TAK1-TRAF6 signalling pathway."Int. J. Biochem. Cell Biol. 42:585-589(2010) [PubMed] [Europe PMC] [Abstract]
  38. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  39. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  40. "TRIM5 is an innate immune sensor for the retrovirus capsid lattice."Nature 472:361-365(2011) [PubMed] [Europe PMC] [Abstract]
  41. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  42. "Lys48-linked TAK1 polyubiquitination at lysine-72 downregulates TNFalpha-induced NF-kappaB activation via mediating TAK1 degradation."Cell. Signal. 24:1381-1389(2012) [PubMed] [Europe PMC] [Abstract]
  43. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  44. "Structural basis for the interaction of TAK1 kinase with its activating protein TAB1."J. Mol. Biol. 354:1013-1020(2005) [PubMed] [Europe PMC] [Abstract]