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Cytochrome P450 51A1 (CYP51A1)

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CYP51; P45014DM; CYPL1; P450L1; LDM; P450-14DM; Lanosterol 14 Alpha-Demethylase; Cytochrome P450 Family 51 Subfamily A Polypeptide 1; Sterol 14-alpha demethylase

Cytochrome P450 51A1 (CYP51A1)
CCC D535
HGNC 2649
MGI 106040
PubMed 9527767
RGD 2481
UniProt Q16850
Wiki CYP51A1
CYP51A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. It is a target for antifungal drugs, inhibiting the production of ergosterol. Over-expression of CYP51A1 can lead to resistance to these antifungals.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 51A1 (CYP51A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 51A1 (CYP51A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 51A1 (CYP51A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 51A1 (CYP51A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 51A1 (CYP51A1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 51A1 (CYP51A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 51A1 (CYP51A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 51A1 (CYP51A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 51A1 (CYP51A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 51A1 (CYP51A1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 51A1 (CYP51A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 51A1 (CYP51A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 51A1 (CYP51A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 51A1 (CYP51A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 51A1 (CYP51A1) ELISA Kit Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 51A1 (CYP51A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 51A1 (CYP51A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 51A1 (CYP51A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 51A1 (CYP51A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 51A1 (CYP51A1) ELISA Kit Customized Service Offer
  1. "The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols."Arch. Biochem. Biophys. 329:73-81(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Sterol 14-demethylase P450 (P45014DM*) is one of the most ancient and conserved P450 species."J. Biochem. 119:926-933(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The three human cytochrome P450 lanosterol 14 alpha-demethylase (CYP51) genes reside on chromosomes 3, 7, and 13: structure of the two retrotransposed pseudogenes, association with a line-1 element, and evolution of the human CYP51 family."Arch. Biochem. Biophys. 333:466-474(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Structure and mapping of the human lanosterol 14alpha-demethylase gene (CYP51) encoding the cytochrome P450 involved in cholesterol biosynthesis; comparison of exon/intron organization with other mammalian and fungal CYP genes."Genomics 38:371-381(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Structural basis of human CYP51 inhibition by antifungal azoles."J. Mol. Biol. 397:1067-1078(2010) [PubMed] [Europe PMC] [Abstract]