≡

5-Hydroxytryptamine Receptor 3A (HTR3A)

[Edit]

HTR3; 5-HT-3; 5-HT3A; 5-HT3R; 5HT3R; Serotonin Receptor 3A; Serotonin-gated ion channel receptor

5-Hydroxytryptamine Receptor 3A (HTR3A)
CCC D489
HGNC 5297
MGI 96282
PubMed 11207027
RGD 61818
UniProt P46098
Wiki HTR3A
5-hydroxytryptamine receptor 3A is a protein that belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.
This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Hydroxytryptamine Receptor 3A (HTR3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Hydroxytryptamine Receptor 3A (HTR3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Hydroxytryptamine Receptor 3A (HTR3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Hydroxytryptamine Receptor 3A (HTR3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Hydroxytryptamine Receptor 3A (HTR3A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Hydroxytryptamine Receptor 3A (HTR3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Hydroxytryptamine Receptor 3A (HTR3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Hydroxytryptamine Receptor 3A (HTR3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Hydroxytryptamine Receptor 3A (HTR3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Hydroxytryptamine Receptor 3A (HTR3A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Hydroxytryptamine Receptor 3A (HTR3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Hydroxytryptamine Receptor 3A (HTR3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Hydroxytryptamine Receptor 3A (HTR3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Hydroxytryptamine Receptor 3A (HTR3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Hydroxytryptamine Receptor 3A (HTR3A) ELISA Kit Customized Service Offer
  1. "Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species."Mol. Pharmacol. 48:407-416(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit."Mol. Pharmacol. 48:1054-1062(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of alternatively spliced human 5HT3 receptor cDNAs."Ann. N. Y. Acad. Sci. 861:234-235(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Exon-intron organization of the human 5-HT3A receptor gene."Neuropharmacology 39:308-315(2000) [PubMed] [Europe PMC] [Abstract]
  5. "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes."Genomics 83:566-571(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The 5-HT3B subunit is a major determinant of serotonin-receptor function."Nature 397:359-363(1999) [PubMed] [Europe PMC] [Abstract]
  10. "The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit."J. Biol. Chem. 274:30799-30810(1999) [PubMed] [Europe PMC] [Abstract]
  11. "A cytoplasmic region determines single-channel conductance in 5-HT3 receptors."Nature 424:321-324(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3."J. Biol. Chem. 280:22502-22507(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E."Mol. Pharmacol. 72:8-17(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients."Clin. Rheumatol. 23:338-344(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression."Biol. Psychiatry 60:192-201(2006) [PubMed] [Europe PMC] [Abstract]