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Protease, Serine 3 (PRSS3)

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PRSS4; TRY3, TRY4; Mesotrypsin; Trypsin 4,Brain; Brain trypsinogen; Mesotrypsinogen; Serine protease 3; Serine protease 4

Protease, Serine 3 (PRSS3)
CCC D465
HGNC 9486
MGI 1914623
PubMed 20947888
UniProt P35030
Wiki PRSS3
Although this locus appears to encode a protein similar to trypsinogen, the locus is thought to be a transcribed pseudogene. ESTs support its transcription, but expression of its predicted protein has not been observed. Its predicted protein sequence differs significantly from the known functional trypsinogens, including a different amino acid at the conserved residue 122 which is important for autolysis. This pseudogene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.
PRSS3were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protease, Serine 3 (PRSS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protease, Serine 3 (PRSS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protease, Serine 3 (PRSS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protease, Serine 3 (PRSS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protease, Serine 3 (PRSS3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protease, Serine 3 (PRSS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protease, Serine 3 (PRSS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protease, Serine 3 (PRSS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protease, Serine 3 (PRSS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protease, Serine 3 (PRSS3) ELISA Kit Customized Service Offer
  1. "Cloning of the cDNA encoding human brain trypsinogen and characterization of its product."Gene 136:167-175(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Nucleotide sequence of the human pancreatic trypsinogen III cDNA."Nucleic Acids Res. 18:1631-1631(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Keratinocytes synthesize enteropeptidase and multiple forms of trypsinogen during terminal differentiation."J. Invest. Dermatol. 130:944-952(2010) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Paneth cell trypsin is the processing enzyme for human defensin-5."Nat. Immunol. 3:583-590(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors."J. Biol. Chem. 278:48580-48589(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure reveals basis for the inhibitor resistance of human brain trypsin."J. Mol. Biol. 315:1209-1218(2002) [PubMed] [Europe PMC] [Abstract]