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Myosin XVIIIB (MYO18B)

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Myosin XVIIIB (MYO18B)
CCC D459
HGNC 18150
MGI 1921626
PubMed 12547197
RGD 1594542
UniProt Q8IUG5
Wiki MYO18B
Myosin-XVIIIb is a protein protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.The full-length cDNA encodes a deduced 2,567-amino acid protein with a calculated molecular mass of about 285 kD.
MYO18B has an N-terminal head (motor) domain, a neck region containing an IQ motif, and a C-terminal tail containing a short coiled-coil domain that allows dimerization to form a 2-headed structure. The head region contains a consensus ATP-binding site, part of an actin-binding region, and a GPA (gly-pro-ala) motif that is believed to interact with F actin. MYO18B shares 40% identity with the human and mouse MYSPDZ (TIAF1) proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin XVIIIB (MYO18B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin XVIIIB (MYO18B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin XVIIIB (MYO18B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin XVIIIB (MYO18B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin XVIIIB (MYO18B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin XVIIIB (MYO18B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin XVIIIB (MYO18B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin XVIIIB (MYO18B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin XVIIIB (MYO18B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin XVIIIB (MYO18B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin XVIIIB (MYO18B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin XVIIIB (MYO18B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin XVIIIB (MYO18B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin XVIIIB (MYO18B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin XVIIIB (MYO18B) ELISA Kit Customized Service Offer
  1. "MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer."Proc. Natl. Acad. Sci. U.S.A. 99:12269-12274(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation."J. Mol. Biol. 326:137-149(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Genetic alterations responsible for metastatic phenotypes of lung cancer cells."Clin. Exp. Metastasis 20:189-193(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]