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Myosin VI (MYO6)

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DFNA22; DFNB37; Deafness,Autosomal Recessive 37

Myosin VI (MYO6)
CCC D441
HGNC 7605
MGI 104785
PubMed 9259267
RGD 1560646
UniProt Q9UM54
Wiki MYO6
Myosin VI, also known as MYO6, is a protein. It has been found in humans, mice, fruit flies, and nematodes. Myosin VI is a molecular motor involved in intracellular vesicle and organelle transport. It is one of the so-called unconventional myosins.the sequence of the mouse Myo6 gene is 87% identical to that of the pig.
The mouse cDNA predicted a protein of 1,266 amino acids with a relative molecular mass of 142 kD. In the pig, rat, and mouse, myosin VI is widely expressed. In the mouse, within the cochlea of the inner ear, myosin VI is expressed specifically within the sensory hair cells.Expression of MYO6 in human fetal cochlea demonstrated the importance of myosin VI in the mammalian inner ear and supported its potential role in human inner ear pathology.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin VI (MYO6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin VI (MYO6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin VI (MYO6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin VI (MYO6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin VI (MYO6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin VI (MYO6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin VI (MYO6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin VI (MYO6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin VI (MYO6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin VI (MYO6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin VI (MYO6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin VI (MYO6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin VI (MYO6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin VI (MYO6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin VI (MYO6) ELISA Kit Customized Service Offer
  1. "Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice."Hum. Mol. Genet. 6:1225-1231(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." Genome Res. 16:55-65(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Myosin VI is an actin-based motor that moves backwards."Nature 401:505-508(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis."EMBO J. 20:3676-3684(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton."Traffic 3:331-341(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Myosin VI regulates endocytosis of the cystic fibrosis transmembrane conductance regulator."J. Biol. Chem. 279:38025-38031(2004) [PubMed] [Europe PMC] [Abstract]
  10. "A monomeric myosin VI with a large working stroke."EMBO J. 23:1729-1738(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Nuclear myosin VI enhances RNA polymerase II-dependent transcription."Mol. Cell 23:749-755(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Myosin VI is a mediator of the p53-dependent cell survival pathway."Mol. Cell. Biol. 26:2175-2186(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss."Am. J. Hum. Genet. 69:635-640(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations of MYO6 are associated with recessive deafness, DFNB37."Am. J. Hum. Genet. 72:1315-1322(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Novel association of hypertrophic cardiomyopathy, sensorineural deafness, and a mutation in unconventional myosin VI (MYO6)."J. Med. Genet. 41:309-314(2004) [PubMed] [Europe PMC] [Abstract]