Proenkephalin (PENK)
[Edit]Preproenkephalin; Proenkephalin-A; Synenkephalin; Met-enkephalin; Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; Met-enkephalin-Arg-Phe
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Preproenkephalin has 267 amino acids, as does proopiomelanocortin. Both genes contain 2 introns. In both, all the repeated enkephalin or melanotropin sequences are encoded by a single large exon (exon 3). Preproenkephalin mRNA encodes 4 copies of met-enkephalin, 2 copies of met-enkephalin extended sequences, and 1 copy of leu-enkephalin. Each copy is flanked by paired basic amino acids which are presumably recognized by the processing protease.
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The corresponding amino acid sequence shows that the precursor is 267 amino acids long and contains 6 interspersed Met-enkephalin sequences and 1 Leu-enkephalin sequence. The precursor does not contain the sequences of dynorphin, alpha-neo-endorphin or beta-endorphin.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD396Hu01 | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAD396Hu01 | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. |
| MAD396Hu21 | Monoclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. | |
| Assay Kits | SED396Hu | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| CED396Hu | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD396Mu01 | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPD396Mu02 | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAD396Mu01 | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. |
| PAD396Mu02 | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. | |
| Assay Kits | SED396Mu | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD396Ra01 | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Proenkephalin (PENK) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Proenkephalin (PENK) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Proenkephalin (PENK) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Proenkephalin (PENK) | ELISA Kit Customized Service Offer |
- "Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA."Nature 295:663-666(1982) [PubMed] [Europe PMC] [Abstract]
- "Isolation and structural organization of the human preproenkephalin gene."Nature 297:431-434(1982) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "The structure of synenkephalin (pro-enkephalin 1-73) is dictated by three disulfide bonds."Biochem. Biophys. Res. Commun. 232:800-805(1997) [PubMed] [Europe PMC] [Abstract]