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Protein Kinase, AMP Activated Alpha 2 (PRKAa2)

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AMPK; AMPK2; PRKAA; 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2; Acetyl-CoA carboxylase kinase; Hydroxymethylglutaryl-CoA reductase kinase

Protein Kinase, AMP Activated Alpha 2 (PRKAa2)
CCC D357
HGNC 9377
MGI 1336173
PubMed 20842448
RGD 620893
UniProt P54646
Wiki PRKAA2
5'-AMP-activated protein kinase catalytic subunit alpha-2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD357Hu01 Recombinant Protein Kinase, AMP Activated Alpha 2 (PRKAa2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD357Hu01 Polyclonal Antibody to Protein Kinase, AMP Activated Alpha 2 (PRKAa2) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits n/a CLIA Kit for Protein Kinase, AMP Activated Alpha 2 (PRKAa2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, AMP Activated Alpha 2 (PRKAa2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, AMP Activated Alpha 2 (PRKAa2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, AMP Activated Alpha 2 (PRKAa2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, AMP Activated Alpha 2 (PRKAa2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, AMP Activated Alpha 2 (PRKAa2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, AMP Activated Alpha 2 (PRKAa2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, AMP Activated Alpha 2 (PRKAa2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, AMP Activated Alpha 2 (PRKAa2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, AMP Activated Alpha 2 (PRKAa2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, AMP Activated Alpha 2 (PRKAa2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, AMP Activated Alpha 2 (PRKAa2) ELISA Kit Customized Service Offer
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  26. "N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells."Biochem. J. 449:741-749(2013) [PubMed] [Europe PMC] [Abstract]
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