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Protein Kinase, AMP Activated Gamma 2 (PRKAg2)

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AAKG; AAKG2; CMH6; H91620p; WPWS; 5'-AMP-activated protein kinase subunit gamma-2

Protein Kinase, AMP Activated Gamma 2 (PRKAg2)
CCC D356
HGNC 9386
MGI 1336153
PubMed 12015471
RGD 727782
UniProt Q9UGJ0
Wiki PRKAG2
AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. PRKAG2 is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, AMP Activated Gamma 2 (PRKAg2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, AMP Activated Gamma 2 (PRKAg2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, AMP Activated Gamma 2 (PRKAg2) Polyclonal Antibody Customized Service Offer
Assay Kits SED356Hu ELISA Kit for Protein Kinase, AMP Activated Gamma 2 (PRKAg2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD356Mu01 Recombinant Protein Kinase, AMP Activated Gamma 2 (PRKAg2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD356Mu01 Polyclonal Antibody to Protein Kinase, AMP Activated Gamma 2 (PRKAg2) WB; IHC; ICC; IP.
PAD356Mu02 Polyclonal Antibody to Protein Kinase, AMP Activated Gamma 2 (PRKAg2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Kinase, AMP Activated Gamma 2 (PRKAg2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, AMP Activated Gamma 2 (PRKAg2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, AMP Activated Gamma 2 (PRKAg2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, AMP Activated Gamma 2 (PRKAg2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, AMP Activated Gamma 2 (PRKAg2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, AMP Activated Gamma 2 (PRKAg2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, AMP Activated Gamma 2 (PRKAg2) ELISA Kit Customized Service Offer
  1. "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding."Biochem. J. 346:659-669(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning, genomic organization, and mapping of PRKAG2, a heart abundant gamma-2 subunit of 5'-AMP-activated protein kinase, to human chromosome 7q36."Genomics 70:258-263(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations."J. Clin. Invest. 113:274-284(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit."EMBO J. 26:806-815(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop."Autophagy 7:696-706(2011) [PubMed] [Europe PMC] [Abstract]
  12. "AMP-activated protein kinase in metabolic control and insulin signaling."Circ. Res. 100:328-341(2007) [PubMed] [Europe PMC] [Abstract]
  13. "AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy."Nat. Rev. Mol. Cell Biol. 8:774-785(2007) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Novel PRKAG2 mutation responsible for the genetic syndrome of ventricular preexcitation and conduction system disease with childhood onset and absence of cardiac hypertrophy."Circulation 104:3030-3033(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis."Hum. Mol. Genet. 10:1215-1220(2001) [PubMed] [Europe PMC] [Abstract]
  17. "Identification of a gene responsible for familial Wolff-Parkinson-White syndrome."N. Engl. J. Med. 344:1823-1831(2001) [PubMed] [Europe PMC] [Abstract]
  18. ErratumN. Engl. J. Med. 345:552-552(2001)
  19. ErratumN. Engl. J. Med. 346:300-300(2002)
  20. "Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy."J. Clin. Invest. 109:357-362(2002) [PubMed] [Europe PMC] [Abstract]
  21. "Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency."Am. J. Hum. Genet. 76:1034-1049(2005) [PubMed] [Europe PMC] [Abstract]