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Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1)

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ACCN; ASIC2; ASIC2a; BNC1; BNaC1; MDEG; hBNaC1; Degenerin; Acid-sensing ion channel 2; Amiloride-sensitive brain sodium channel; Mammalian degenerin homolog

Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1)
CCC D340
HGNC 99
MGI 1100867
PubMed 17534430
RGD 2017
UniProt Q16515
Wiki ACCN1
Amiloride-sensitive cation channel 1, neuronal is a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing.
ACCN1may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amiloride Sensitive Cation Channel Protein 1, Neuronal (ACCN1) ELISA Kit Customized Service Offer
  1. "Cloning and expression of a novel human brain Na+ channel."J. Biol. Chem. 271:7879-7882(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans."J. Biol. Chem. 271:10433-10436(1996) [PubMed] [Europe PMC] [Abstract]
  3. "BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels."Proc. Natl. Acad. Sci. U.S.A. 94:1459-1464(1997) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+."J. Biol. Chem. 275:28519-28525(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)."Biochem. J. 361:443-450(2002) [PubMed] [Europe PMC] [Abstract]