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Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2)

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ASIC; ASIC1A; BNaC2; hBNaC2; Acid-sensing ion channel 1; Brain sodium channel 2

Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2)
CCC D339
HGNC 100
MGI 1194915
PubMed 18349698
RGD 71062
UniProt P78348
Wiki ACCN2
Amiloride-sensitive cation channel 2, neuronal is a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing.
The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Alternative splicing of this gene generates 2 transcript products.Expressed in most or all neurons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amiloride Sensitive Cation Channel Protein 2, Neuronal (ACCN2) ELISA Kit Customized Service Offer
  1. "BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels."Proc. Natl. Acad. Sci. U.S.A. 94:1459-1464(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant."J. Biol. Chem. 285:41852-41862(2010) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels."Neuron 26:133-141(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)."Biochem. J. 361:443-450(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Protein kinase C isoform antagonism controls BNaC2 (ASIC1) function."J. Biol. Chem. 277:45734-45740(2002) [PubMed] [Europe PMC] [Abstract]
  8. "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1."Proc. Natl. Acad. Sci. U.S.A. 100:2029-2034(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Selective regulation of acid-sensing ion channel 1 by serine proteases."J. Biol. Chem. 279:38448-38457(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Structure of the acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1."Nat. Commun. 3:936-936(2012) [PubMed] [Europe PMC] [Abstract]