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Amiloride Sensitive Sodium Channel Subunit Delta (SCNN1d)

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ENaCd; ENaCdelta; SCNED; dNaCh; Sodium Channel,Nonvoltage-Gated 1,Delta; Epithelial Na(+) channel subunit delta; Nonvoltage-gated sodium channel 1 subunit delta

Amiloride Sensitive Sodium Channel Subunit Delta (SCNN1d)
CCC D334
HGNC 10601
PubMed 19548526
UniProt P51172
Wiki SCNN1D
Amiloride-sensitive sodium channel subunit delta is a protein encoded by the SCNN1D gene.The epithelial sodium channel (short: ENaC, also: sodium channel non-neuronal 1 (SCNN1) or amiloride sensitive sodium channel (ASSC)) is a membrane-bound ion-channel that is permeable for Li+-ions, protons and especially Na+-ions. It is a constitutively active ion-channel. It is arguably the most selective ion channel.
The apical membrane of many tight epithelia contains sodium channels that are primarily characterised by their high affinity to the diuretic blocker amiloride. These channels mediate the first step of active sodium reabsorption essential for the maintenance of body salt and water homeostasis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amiloride Sensitive Sodium Channel Subunit Delta (SCNN1d) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Delta (SCNN1d) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Delta (SCNN1d) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amiloride Sensitive Sodium Channel Subunit Delta (SCNN1d) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amiloride Sensitive Sodium Channel Subunit Delta (SCNN1d) ELISA Kit Customized Service Offer
  1. "Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel."J. Biol. Chem. 270:27411-27414(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction."J. Biol. Chem. 281:8233-8241(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the epithelial sodium channel delta-subunit in human nasal epithelium."Am. J. Respir. Cell Mol. Biol. 42:498-505(2010) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of a novel splice variant of delta ENaC subunit in human lungs."Am. J. Physiol. 302:L1262-L1272(2012) [PubMed] [Europe PMC] [Abstract]