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Proteasome Activator Subunit 1 (PSME1)

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IFI5111; PA28A; 11S regulator complex subunit alpha; Activator of multicatalytic protease subunit 1; Interferon gamma up-regulated I-5111; Proteasome activator 28 subunit alpha

Proteasome Activator Subunit 1 (PSME1)
CCC D325
HGNC 9568
MGI 1096367
PubMed 15373739
RGD 3429
UniProt Q06323
Wiki PSME1
Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. PSME1 encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome Activator Subunit 1 (PSME1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome Activator Subunit 1 (PSME1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Activator Subunit 1 (PSME1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Activator Subunit 1 (PSME1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Activator Subunit 1 (PSME1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome Activator Subunit 1 (PSME1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome Activator Subunit 1 (PSME1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Activator Subunit 1 (PSME1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Activator Subunit 1 (PSME1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Activator Subunit 1 (PSME1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome Activator Subunit 1 (PSME1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome Activator Subunit 1 (PSME1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Activator Subunit 1 (PSME1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Activator Subunit 1 (PSME1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Activator Subunit 1 (PSME1) ELISA Kit Customized Service Offer
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  9. "The proteasome 11S regulator subunit REG alpha (PA28 alpha) is a heptamer."Protein Sci. 6:2469-2473(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Structure of the proteasome activator REGalpha (PA28alpha)."Nature 390:639-643(1997) [PubMed] [Europe PMC] [Abstract]