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Cyclin K (CCNK)

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CCN-K; CPR4; MGC9113

Cyclin K (CCNK)
CCC D276
HGNC 1596
MGI 1276106
PubMed 9632813
RGD 1595690
UniProt O75909
Wiki Cyclin_K
Cyclin-K is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. The cyclin K gene contains 8 exons. Northern blot analysis indicated that the 2.3-kb cyclin K transcript was present in all human adult tissues tested, with the highest level in testis. Additional 2.9- and 1.4-kb mRNAs were also detected in some tissues. Using in situ hybridization, the authors found that cyclin K mRNA is highly expressed in the developing germ cells of adult mouse testis and ovary. The predicted 357-amino acid cyclin K protein shares 99% and 22% identity with mouse cyclin K and human cyclin C, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin K (CCNK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin K (CCNK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin K (CCNK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin K (CCNK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin K (CCNK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin K (CCNK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin K (CCNK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin K (CCNK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin K (CCNK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin K (CCNK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin K (CCNK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin K (CCNK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin K (CCNK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin K (CCNK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin K (CCNK) ELISA Kit Customized Service Offer
  1. "Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity."Mol. Cell. Biol. 18:4291-4300(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription."J. Biol. Chem. 274:34527-34530(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes."Genes Dev. 25:2158-2172(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9."J. Mol. Biol. 366:563-573(2007) [PubMed] [Europe PMC] [Abstract]
  15. "The structure and substrate specificity of human Cdk12/Cyclin K."Nat. Commun. 5:3505-3505(2014) [PubMed] [Europe PMC] [Abstract]