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Cyclin L1 (CCNL1)

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CCN-L1; BM-001; Ania-6a

Cyclin L1 (CCNL1)
CCC D274
HGNC 20569
MGI 1922664
PubMed 16598186
RGD 620864
UniProt Q9UK58
Wiki CCNL1
Cyclin L, a novel cyclin related to the C-type cyclins that are involved in regulation of RNA polymerase II (pol II) transcription. Cyclin L also contains a COOH-terminal dipeptide repeat of alternating arginines and serines, a hallmark of the SR family of splicing factors. cyclin L interacts with p110 PITSLRE kinase, and that cyclin L antibody co-immunoprecipitates a kinase activity from HeLa nuclear extracts that phosphorylates the carboxyl-terminal domain (CTD) of pol II and splicing factor SC35, and is inhibited by the cdk inhibitor p21. Cyclin L antibody inhibits the second step of RNA splicing in vitro, and recombinant cyclin L protein stimulates splicing under suboptimal conditions.Cyclin L and its associated kinase are thus new members of the pre-mRNA processing machinery.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin L1 (CCNL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin L1 (CCNL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin L1 (CCNL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin L1 (CCNL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin L1 (CCNL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin L1 (CCNL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin L1 (CCNL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin L1 (CCNL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin L1 (CCNL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin L1 (CCNL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin L1 (CCNL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin L1 (CCNL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin L1 (CCNL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin L1 (CCNL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin L1 (CCNL1) ELISA Kit Customized Service Offer
  1. "Cyclin L is an RS domain protein involved in pre-mRNA splicing."J. Biol. Chem. 277:25465-25473(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer."Cancer Res. 62:6211-6217(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC)."Br. J. Cancer 92:770-774(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]