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G Protein Coupled Receptor Kinase 1 (GRK1)

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RHOK; GPRK1; RK; Rhodopsin Kinase

G Protein Coupled Receptor Kinase 1 (GRK1)
CCC D257
HGNC 10013
MGI 1345146
PubMed 21504899
RGD 619712
UniProt Q15835
Wiki GRK1
Light-dependent deactivation of rhodopsin as well as homologous desensitization of beta-adrenergic receptors involves receptor phosphorylation that is mediated by the highly specific protein kinases rhodopsin kinase (RHOK, or GRK1) and beta-adrenergic receptor kinase (BARK, or ADRBK1), respectively. Lorenz et al. (1991) cloned a cDNA for RHOK. The deduced amino acid sequence showed a high degree of homology to the beta-adrenergic receptor kinase. From similarities to cyclic nucleotide-dependent protein kinase and protein kinase C, they concluded that RHOK and BARK are members of a newly delineated gene family of guanine nucleotide-binding protein (G protein)-coupled receptor kinases that may function in diverse pathways to regulate the function of such receptors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor Kinase 1 (GRK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor Kinase 1 (GRK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor Kinase 1 (GRK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor Kinase 1 (GRK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor Kinase 1 (GRK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor Kinase 1 (GRK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor Kinase 1 (GRK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor Kinase 1 (GRK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor Kinase 1 (GRK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor Kinase 1 (GRK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor Kinase 1 (GRK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor Kinase 1 (GRK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor Kinase 1 (GRK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor Kinase 1 (GRK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor Kinase 1 (GRK1) ELISA Kit Customized Service Offer
  1. "Molecular cloning and localization of rhodopsin kinase in the mammalian pineal."Vis. Neurosci. 14:225-232(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization and chromosomal localization of the gene for human rhodopsin kinase."Genomics 35:571-576(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells: implications for cone cell phototransduction."J. Neurosci. 21:9175-9184(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities."J. Biol. Chem. 280:28241-28250(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Evaluation of the rhodopsin kinase gene in patients with retinitis pigmentosa."Exp. Eye Res. 65:249-253(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness."Nat. Genet. 15:175-178(1997) [PubMed] [Europe PMC] [Abstract]
  9. "A novel homozygous GRK1 mutation (P391H) in 2 siblings with Oguchi disease with markedly reduced cone responses."Ophthalmology 114:134-141(2007) [PubMed] [Europe PMC] [Abstract]