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Cyclin Dependent Kinase 10 (CDK10)

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PISSLRE; Cell division protein kinase 10; Serine/threonine-protein kinase PISSLRE

Cyclin Dependent Kinase 10 (CDK10)
CCC D242
HGNC 1770
MGI 2448549
PubMed 18242510
RGD 1304851
UniProt Q15131
Wiki CDK10
Cyclin-dependent kinases (CDKs) are CDC2-related kinases that bind to cyclin to form active holoenzymes that play a pivotal role in the regulation of the eukaryotic cell cycle.
Cell division protein kinase 10 is an enzyme belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin Dependent Kinase 10 (CDK10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin Dependent Kinase 10 (CDK10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin Dependent Kinase 10 (CDK10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 10 (CDK10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 10 (CDK10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin Dependent Kinase 10 (CDK10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin Dependent Kinase 10 (CDK10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin Dependent Kinase 10 (CDK10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 10 (CDK10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 10 (CDK10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin Dependent Kinase 10 (CDK10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin Dependent Kinase 10 (CDK10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin Dependent Kinase 10 (CDK10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 10 (CDK10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 10 (CDK10) ELISA Kit Customized Service Offer
  1. "PISSLRE, a human novel CDC2-related protein kinase."Oncogene 9:2097-2103(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases."Oncogene 9:3037-3041(1994) [PubMed] [Europe PMC] [Abstract]
  3. "The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer."Genomics 56:90-97(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome."Proc. Natl. Acad. Sci. U.S.A. 110:19525-19530(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]