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Leukotriene B4 Receptor (LTB4R)

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BLT1; BLTR; CMKRL1; GPR16; LTBR1; LTB4-R1; P2RY7; P2Y7; Chemokine Receptor-Like 1; Chemoattractant receptor-like 1; G-protein coupled receptor 16; P2Y purinoceptor 7

Leukotriene B4 Receptor (LTB4R)
CCC D239
HGNC 6713
MGI 1309472
PubMed 24598577
RGD 620410
UniProt Q15722
Wiki LTB4R
Using degenerate PCR to find cDNAs encoding new G protein coupled-receptors in human B cells, Owman et al. (1996) identified a CMKRL1 cDNA which encodes a 352-amino acid polypeptide with a calculated mass of 43 kD. The nearest homologs of this novel sequence are the chemoattractant leukocyte receptors, such as the C5a anaphylatoxin receptor and the FMLP receptor.
Northern blot analysis revealed transcripts of 5 kb and 7.5 kb in several tissues of the immune system including spleen, thymus, and lymph node. Owman et al. (1996) considered the high level of expression in lymphoid tissues suggestive of the role of CMKRL1 in the regulation of the inflammatory system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leukotriene B4 Receptor (LTB4R) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leukotriene B4 Receptor (LTB4R) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leukotriene B4 Receptor (LTB4R) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leukotriene B4 Receptor (LTB4R) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leukotriene B4 Receptor (LTB4R) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leukotriene B4 Receptor (LTB4R) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leukotriene B4 Receptor (LTB4R) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leukotriene B4 Receptor (LTB4R) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leukotriene B4 Receptor (LTB4R) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leukotriene B4 Receptor (LTB4R) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leukotriene B4 Receptor (LTB4R) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leukotriene B4 Receptor (LTB4R) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leukotriene B4 Receptor (LTB4R) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leukotriene B4 Receptor (LTB4R) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leukotriene B4 Receptor (LTB4R) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells."J. Biol. Chem. 271:18363-18367(1996) [PubMed] [Europe PMC] [Abstract]
  2. "New members of the chemokine receptor gene family."J. Leukoc. Biol. 59:18-23(1996) [PubMed] [Europe PMC] [Abstract]
  3. "A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis."Nature 387:620-624(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning of cDNA encoding a putative chemoattractant receptor."Genomics 37:187-194(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene."J. Exp. Med. 192:413-420(2000) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization."J. Biol. Chem. 277:31567-31576(2002) [PubMed] [Europe PMC] [Abstract]