Complement Receptor 1 Like Protein (CR1L)

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Complement component receptor 1-like protein; Complement C4b-binding protein CR-1-like protein

Complement Receptor 1 Like Protein (CR1L)
The C3b/C4b receptor (CR1) is important in immune complex processing. On phagocytic cells it promotes the adherence and sometimes the endocytosis of C3b- and C4b-coated particles. CR1 is composed largely of a tandemly repeated motif of approximately 60 amino acids, the short consensus repeat (SCR).
In the course of cloning genomic CR1 sequences, Hourcade et al. (1990) identified a related gene, CR1L. Analysis of subclones identified 10 exons encoding a signal peptide and SCR1 through SCR6 and SCR9, which are 91% homologous to the corresponding N-terminal regions of the CR1 protein. Hourcade et al. (1990) concluded that CR1L arose by a gene duplication event and has undergone mutation at the beginning of SCR1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Complement Receptor 1 Like Protein (CR1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Complement Receptor 1 Like Protein (CR1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complement Receptor 1 Like Protein (CR1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Complement Receptor 1 Like Protein (CR1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Receptor 1 Like Protein (CR1L) ELISA Kit Customized Service Offer
  1. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "A human CR1-like transcript containing sequence for a binding protein for iC4 is expressed in hematopoietic and fetal lymphoid tissue."Mol. Immunol. 40:831-840(2004) [PubMed] [Europe PMC] [Abstract]