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Leukotriene C4 Synthase (LTC4S)

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Leukotriene C4 Synthase (LTC4S)
CCC D235
HGNC 6719
MGI 107498
PubMed 22722751
RGD 620677
UniProt Q16873
Wiki LTC4S
LTC4S is an enzyme which converts leukotriene A4 and glutathione to create leukotriene C4. This is a member of MAPEG family of transmembrane proteins. A trimer of Leukotriene C4 synthase is localized on the outer nuclear membrane and endoplasmic reticulum where it forms a complex with 5-Lipoxygenase activating protein. This protein is remotely related to microsomal glutathione S-transferase. LTC4S is an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leukotriene C4 Synthase (LTC4S) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leukotriene C4 Synthase (LTC4S) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leukotriene C4 Synthase (LTC4S) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leukotriene C4 Synthase (LTC4S) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leukotriene C4 Synthase (LTC4S) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leukotriene C4 Synthase (LTC4S) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leukotriene C4 Synthase (LTC4S) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leukotriene C4 Synthase (LTC4S) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leukotriene C4 Synthase (LTC4S) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leukotriene C4 Synthase (LTC4S) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leukotriene C4 Synthase (LTC4S) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leukotriene C4 Synthase (LTC4S) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leukotriene C4 Synthase (LTC4S) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leukotriene C4 Synthase (LTC4S) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leukotriene C4 Synthase (LTC4S) ELISA Kit Customized Service Offer
  1. "Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4."Proc. Natl. Acad. Sci. U.S.A. 91:7663-7667(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and expression of human leukotriene-C4 synthase."Proc. Natl. Acad. Sci. U.S.A. 91:9745-9749(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35."J. Biol. Chem. 271:11356-11361(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning of the human leukotriene C4 synthase gene and assignment to chromosome 5q35."Mol. Med. 2:637-646(1996) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits."Proc. Natl. Acad. Sci. U.S.A. 90:2015-2019(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody."Am. J. Respir. Crit. Care Med. 152:283-289(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Two step purification of human and murine leukotriene C4 synthase."Biochim. Biophys. Acta 1256:257-261(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Leukotriene C4-synthesis deficiency: a new inborn error of metabolism linked to a fatal developmental syndrome."Lancet 352:1514-1517(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Defects in the synthesis of cysteinyl leukotrienes: a new group of inborn errors of metabolism."J. Inherit. Metab. Dis. 23:404-408(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Membrane localization and topology of leukotriene C4 synthase."J. Biol. Chem. 277:28902-28908(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein."Biochem. Biophys. Res. Commun. 381:518-522(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis."Nature 448:609-612(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase."Nature 448:613-616(2007) [PubMed] [Europe PMC] [Abstract]